# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5151455 | B | Displacement of [3H] mepyramine from human histamine H1 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RGS4 incubated for 60 mins by scintillation counting analysis | Homo sapiens | 43 | ALA5149991 | cell membrane format | Scientific Literature | |
2. | ALA5151456 | B | Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S incubated for 60 mins by scintillation counting analysis | Homo sapiens | 43 | ALA5149991 | cell membrane format | Scientific Literature | |
3. | ALA5151458 | B | Displacement of [3H]UR-PI294 from human histamine H3 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis | Homo sapiens | 38 | ALA5149991 | cell membrane format | Scientific Literature | |
4. | ALA5151459 | B | Displacement of [3H]-histamine from human histamine H4 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing G-alphai2 and G-beta1gamma2 incubated for 60 mins by scintillation counting analysis | Homo sapiens | 43 | ALA5149991 | cell membrane format | Scientific Literature | |
5. | ALA5151460 | B | Selectivity ratio of Ki for human histamine H4 receptor to Ki for human histamine H2 receptor incubated for 60 mins by scintillation counting analysis | Homo sapiens | 42 | ALA5149991 | assay format | Scientific Literature | |
6. | ALA5151461 | B | Selectivity ratio of Ki for human histamine H1 receptor to Ki for human histamine H2 receptor incubated for 60 mins by scintillation counting analysis | Homo sapiens | 42 | ALA5149991 | assay format | Scientific Literature | |
7. | ALA5151462 | B | Selectivity ratio of Ki for human histamine H3 receptor to Ki for human histamine H2 receptor incubated for 60 mins by scintillation counting analysis | Homo sapiens | 42 | ALA5149991 | assay format | Scientific Literature | |
8. | ALA5151463 | P | Chemical stability in pH 7.4 buffer measured at 0 to 2 weeks by HPLC analysis | 9 | ALA5149991 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5151464 | B | Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 mins by radioligand competition binding based assay | Homo sapiens | 14 | ALA5149991 | cell-based format | Scientific Literature | |
10. | ALA5151465 | B | Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK at high concentration incubated for 140 mins by radioligand competition binding based assay | Homo sapiens | 14 | ALA5149991 | cell-based format | Scientific Literature | |
11. | ALA5151466 | B | Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 mins by radioligand competition binding based assay | Homo sapiens | 14 | ALA5149991 | cell-based format | Scientific Literature | |
12. | ALA5151468 | F | Agonist activity at guinea pig histamine H2 receptor stably transfected in HEK293T cells co-expressing NlucN-mGs/gpH2R-NlucC assessed as maximum efficacy at 100 uM by mini-G protein recruitment assay relative to histamine | Cavia porcellus | 8 | ALA5149991 | cell-based format | Scientific Literature | |
13. | ALA5151469 | B | Selectivity ratio of Ki for human D2 long receptor receptor to Ki for human histamine H2 receptor | Homo sapiens | 14 | ALA5149991 | assay format | Scientific Literature | |
14. | ALA5151470 | B | Selectivity ratio of Ki for human D3 receptor receptor to Ki for human histamine H2 receptor | Homo sapiens | 14 | ALA5149991 | assay format | Scientific Literature | |
15. | ALA5151471 | F | Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing ARRB2 incubated for 60 mins by beta-arrestin2 recruitment assay | Homo sapiens | 14 | ALA5149991 | cell-based format | Scientific Literature | |
16. | ALA5151472 | F | Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing ARRB2 assessed as maximum efficacy at 100 uM incubated for 60 mins by beta-arrestin2 recruitment assay relative to histamine | Homo sapiens | 14 | ALA5149991 | cell-based format | Scientific Literature | |
17. | ALA5151473 | F | Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing NlucN-mGs/hH2R-NlucC assessed as induction of mini-Gi protein recruitment using furimazine as substrate measured for 45 mins by luminescence assay | Homo sapiens | 15 | ALA5149991 | cell-based format | Scientific Literature | |
18. | ALA5151474 | F | Agonist activity at human histamine H2 receptor stably expressed in HEK293T cells co-expressing NlucN-mGs/hH2R-NlucC assessed as induction of mini-Gi protein recruitment by measuring maximum efficacy at 100 uM using furimazine as substrate measured for 45 mins by luminescence assay relative to histamine | Homo sapiens | 15 | ALA5149991 | cell-based format | Scientific Literature | |
19. | ALA5151475 | F | Agonist activity at guinea pig histamine H2 receptor stably transfected in HEK293T cells co-expressing NlucN-mGs/gpH2R-NlucC by mini-G protein recruitment assay | Cavia porcellus | 8 | ALA5149991 | cell-based format | Scientific Literature | |
20. | ALA5151476 | F | Agonist activity at histamine H2 receptor in spontaneous beating guinea pig right atrium assessed as increase in heart beat | Cavia porcellus | 8 | ALA5149991 | tissue-based format | Scientific Literature |