| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5145928 | B | Inhibition of recombinant human DGAT1 expressed in Sf9 cell membrane assessed as inhibition of triglyceride synthesis incubated for 1 hrs by LC-MS-based mass spectrophotometric analysis | Homo sapiens | 6 | cell membrane format | Scientific Literature | ||
| 2. | ALA5145929 | B | Inhibition of human DGAT1 in serum starved HEK293 cells assessed as inhibition of triglyceride synthesis incubated for 20 mins followed by 13C-addition of 13C-oleic acid pre-complexed with BSA for 120 mins by LC-MS-based mass spectrophotometric analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA5145930 | B | Inhibition of recombinant human DGAT2 expressed in Sf9 cell membrane assessed as inhibition of triglyceride synthesis at 10 uM for 1 hr by LC-MS-based mass spectrophotometric analysis | Homo sapiens | 5 | cell membrane format | Scientific Literature | ||
| 4. | ALA5145931 | B | Inhibition of recombinant human MGAT2 expressed in Sf9 cell membrane assessed as inhibition of triglyceride synthesis at 10 uM for 1 hr by LC-MS-based mass spectrophotometric analysis | Homo sapiens | 5 | cell membrane format | Scientific Literature | ||
| 5. | ALA5145932 | B | Inhibition of human ACAT1 in HepG2 cells assessed as inhibition of triglyceride synthesis at 100 nM incubated for 1 hrs followed by 13C-addition of 13C-oleic acid pre-complexed with fatty acid free BSA for 6 hrs by LC/MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5145934 | B | Inhibition of human ACAT1 in HepG2 cells assessed as inhibition of triglyceride synthesis at 300 nM incubated for 1 hrs followed by 13C-addition of 13C-oleic acid pre-complexed with fatty acid free BSA for 6 hrs by LC/MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA5145935 | B | Inhibition of human ACAT1 in HepG2 cells assessed as inhibition of triglyceride synthesis at 1 uM incubated for 1 hrs followed by 13C-addition of 13C-oleic acid pre-complexed with fatty acid free BSA for 6 hrs by LC/MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA5145938 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM and measured at 30 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
| 9. | ALA5145939 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 1 uM and measured at 30 mins by LC-MS/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 10. | ALA5145940 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM and measured at 30 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 11. | ALA5145945 | A | Inhibition of recombinant human CYP2D6 at 25 uM by fluorescence plate reader analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA5145947 | T | Displacement of [3H]astemizole from human ERG expressed in HEK293 cell membrane at 30 uM for 2 hrs by Radiometric displacement assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 13. | ALA5145949 | A | Plasma protein binding in rat | Rattus norvegicus | 5 | cell-free format | Scientific Literature | ||
| 14. | ALA5145950 | A | Plasma protein binding in mouse | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 15. | ALA5145951 | A | Clearance in C57BL/6 mouse at 3 mg/kg, iv or 10 mg/kg, po and measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA5145956 | A | Apparent permeability across apical to basolateral side in MDCK cells at 2.5 uM for 90 mins | Canis lupus familiaris | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA5145957 | A | Volume of distribution at steady state in C57BL/6 mouse at 3 mg/kg, iv or 10 mg/kg, po and measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA5145960 | A | AUC in C57BL/6 mouse at 3 mg/kg, iv or 10 mg/kg, po and measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA5145962 | A | Cmax in C57BL/6 mouse at 3 mg/kg, iv or 10 mg/kg, po and measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA5145964 | A | Tmax in C57BL/6 mouse at 3 mg/kg, iv or 10 mg/kg, po and measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature |
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