# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5098262 | F | Antiproliferative activity against ALK-positive human NCI-H3122 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
2. | ALA5098263 | F | Antiproliferative activity against ALK-positive human KARPAS-299 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
3. | ALA5098265 | B | Protac activity at CRBN/EML4-ALK in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation at 1 uM incubated for 16 hrs by Western blot analysis relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
4. | ALA5098266 | B | Protac activity at CRBN/EML4-ALK in human NCI-H3122 cells assessed as induction of EML4-ALK fusion protein degradation at 0.1 uM incubated for 16 hrs by Western blot analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
5. | ALA5098269 | B | Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
6. | ALA5098270 | B | Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 0.1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
7. | ALA5098336 | F | Antiproliferative activity against mouse BaF3 cells expressing wild type EML-ALK assessed as cell viability at 1 uM incubated for 72 hrs by Celltitre-Glo assay relative to control | Mus musculus | 6 | cell-based format | Scientific Literature | ||
8. | ALA5098337 | F | Antiproliferative activity against crizotinib-resistant mouse BaF3 cells expressing EML-ALK L1152R mutant assessed as cell viability at 1 uM incubated for 72 hrs by Celltitre-Glo assay relative to control | Mus musculus | 6 | cell-based format | Scientific Literature | ||
9. | ALA5098338 | F | Antiproliferative activity against crizotinib-resistant mouse BaF3 cells expressing EML-ALK G1202R mutant assessed as cell viability at 1 uM incubated for 72 hrs by Celltitre-Glo assay relative to control | Mus musculus | 6 | cell-based format | Scientific Literature | ||
10. | ALA5098339 | F | Antiproliferative activity against crizotinib-resistant mouse BaF3 cells expressing EML-ALK L1196M mutant assessed as cell viability at 1 uM incubated for 72 hrs by Celltitre-Glo assay relative to control | Mus musculus | 6 | cell-based format | Scientific Literature | ||
11. | ALA5098352 | B | Inhibition of ALK phosphorylation in human KARPAS-299 cells at 0.01 to 1 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
12. | ALA5098353 | B | Inhibition of STAT3 phosphorylation in human KARPAS-299 cells as 0.01 to 1 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature |