# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5130997 | B | Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence based analysis | Homo sapiens | 7 | ALA5126645 | single protein format | Scientific Literature | |
2. | ALA5130999 | A | Prodrug conversion assessed as LSD1 (unknown origin)-mediated vorinostat release incubated for 24 hrs by HPLC analysis | Homo sapiens | 2 | ALA5126645 | single protein format | Scientific Literature | |
3. | ALA5131000 | A | Prodrug conversion assessed as FAD (unknown origin)-mediated vorinostat release incubated for 24 hrs by HPLC analysis | Homo sapiens | 2 | ALA5126645 | assay format | Scientific Literature | |
4. | ALA5131001 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
5. | ALA5131002 | F | Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
6. | ALA5131003 | T | Cytotoxicity against HMEC cells assessed as inhibition of cell growth incubated for 3 days by alamar blue assay | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
7. | ALA5131004 | T | Selectivity index, ratio of IC50 for cytotoxicity against HMEC cells to GI50 for antiproliferative activity against human MDA-MB-231 cells | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
8. | ALA5131005 | T | Selectivity index, ratio of IC50 for cytotoxicity against HMEC cells to GI50 for antiproliferative activity against human NCI-H526 cells | Homo sapiens | 7 | ALA5126645 | cell-based format | Scientific Literature | |
9. | ALA5131006 | B | Inhibition of HDAC1 in human NCI-H526 cells assessed as increase in H3K4 methylation at 16 uM measured after 24 to 72 hrs by Western blot analysis | Homo sapiens | 1 | ALA5126645 | cell-based format | Scientific Literature | |
10. | ALA5131007 | B | Inhibition of HDAC1 in human NCI-H526 cells assessed as increase in H3K9 acetylation at 16 uM measured after 24 to 72 hrs by Western blot analysis | Homo sapiens | 1 | ALA5126645 | cell-based format | Scientific Literature | |
11. | ALA5131008 | B | Potency index, ratio of vorinostat IC50 to test compound IC50 for inhibition of HDAC1 human NCI-H526 cells measured after 24 to 72 hrs by Western blot analysis | Homo sapiens | 1 | ALA5126645 | cell-based format | Scientific Literature | |
12. | ALA5131009 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days in presence of LSD1 inhibitor, NCD38 by alamar blue assay | Homo sapiens | 1 | ALA5126645 | cell-based format | Scientific Literature | |
13. | ALA5131010 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days in presence of vorinostat by alamar blue assay | Homo sapiens | 1 | ALA5126645 | cell-based format | Scientific Literature | |
14. | ALA5131011 | F | Additive antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 3 days in presence of 4-(Chloromethyl)phenyl acetate by alamar blue assay | Homo sapiens | 1 | ALA5126645 | cell-based format | Scientific Literature |