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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA5167322 B Displacement of [3H]Ro151788 from human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay Homo sapiens 38 cell membrane format Scientific Literature 2. ALA5167323 B Negative allosteric modulation activity at human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cells assessed as modulation at alpha5 subunit at 1 uM by Patch clamp method Homo sapiens 38 cell-based format Scientific Literature 3. ALA5167324 B Negative allosteric modulation activity at human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cells assessed as modulation at alpha5 subunit at 10 uM by Patch clamp method Homo sapiens 38 cell-based format Scientific Literature 4. ALA5167325 B Negative allosteric modulation activity at human recombinant alpha1beta3gamma2 GABAA receptor stably expressed in HEK293 cells assessed as modulation at alpha1 subunit at 10 uM by Patch clamp method Homo sapiens 38 cell-based format Scientific Literature 5. ALA5167326 T Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp method Homo sapiens 33 cell-based format Scientific Literature 6. ALA5167327 A Metabolic stability in human liver microsomes assessed as intrinsic clearance at 2.5 uM Homo sapiens 38 microsome format Scientific Literature 7. ALA5167328 A Metabolic stability in Wistar rat liver microsomes assessed as intrinsic clearance at 2.5 uM Rattus norvegicus 38 microsome format Scientific Literature 8. ALA5167329 A Ratio of drug level in brain to plasma in Wistar rat at 3 mg/kg, po measured at 1.5 hr post dose Rattus norvegicus 12 organism-based format Scientific Literature 9. ALA5167330 A Passive permeability in human Caco-2 cells assessed as permeability damage ratio at 10 uM by HPLC-UV analysis Homo sapiens 12 cell-based format Scientific Literature 10. ALA5167331 A Clearance in Wistar rat plasma at 1 mg/kg, iv by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 11. ALA5167332 A Volume of distribution in Wistar rat plasma at 1 mg/kg, iv by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 12. ALA5167333 A Half life in Wistar rat total plasma at 1 mg/kg, iv by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 13. ALA5167334 A Half life in Wistar rat total plasma at 1 mg/kg, po by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 14. ALA5167335 A Tmax in Wistar rat total plasma at 1 mg/kg, po by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 15. ALA5167336 A AUC (0 to infinity) in Wistar rat total plasma at 1 mg/kg, iv by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 16. ALA5167337 A AUC (0 to infinity) in Wistar rat total plasma at 1 mg/kg, po by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 17. ALA5167338 A Cmax in Wistar rat total plasma at 1 mg/kg, po by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 18. ALA5167339 A Bioavailability in Wistar rat total plasma at 1 mg/kg, iv by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 19. ALA5167340 A Ratio of drug level in brain to plasma in Wistar rat at 1 mg/kg, iv by HPLC-MS/MS analysis Rattus norvegicus 3 organism-based format Scientific Literature 20. ALA5167373 A Apparent permeability in human Caco-2 cells at 10 uM by HPLC-UV analysis Homo sapiens 11 cell-based format Scientific Literature