# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5098671 | B | Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of ATP at Km concentration by plate reader analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
2. | ALA5098672 | B | Inhibition of CDK1 (unknown origin) using 5FAM-RRRFRPASPLRGPPK-COOH as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of ATP at Km concentration by plate reader analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
3. | ALA5098673 | B | Inhibition of CDK2 (unknown origin) using FL-Ahx-QSPKKG-CONH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of ATP at Km concentration by plate reader analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
4. | ALA5098674 | B | Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis | Homo sapiens | 37 | single protein format | Scientific Literature | ||
5. | ALA5098675 | B | Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA polymerase II phosphorylation at ser2 residue incubated for 6 hrs by fluorescence based assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
6. | ALA5098676 | B | Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysis | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
7. | ALA5098677 | P | Lipophilicity, logD of the compound in octanol/buffer at pH 7.4 by shake flask method | 38 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA5098678 | P | Solubility of the compound in phosphate buffer at pH 7.4 | 37 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA5098679 | B | Inhibition of CDK7 (unknown origin) using 5FAM-YSPTSPSYSPTSPSYSPTSPSKKKK-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of ATP at Km concentration by plate reader analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
10. | ALA5098680 | B | Inhibition of CDK12 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of ATP at Km concentration by plate reader analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
11. | ALA5098681 | B | Inhibition of CDK6 (unknown origin) at 1 uM incubated for 40 mins in the presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting method relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
12. | ALA5098682 | B | Inhibition of full length human GSK3beta in the presence of ATP at Km concentration | Homo sapiens | 5 | single protein format | Scientific Literature | ||
13. | ALA5098683 | B | Inhibition of CDK1 (unknown origin) using 5FAM-RRRFRPASPLRGPPK-COOH as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
14. | ALA5098684 | B | Inhibition of CDK2 (unknown origin) using FL-Ahx-QSPKKG-CONH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
15. | ALA5098685 | B | Inhibition of CDK7 (unknown origin) using 5FAM-YSPTSPSYSPTSPSYSPTSPSKKKK-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
16. | ALA5098686 | B | Inhibition of CDK12 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
17. | ALA5098687 | P | Dissociation constant, pKa of the compound | 12 | small-molecule physicochemical format | Scientific Literature | |||
18. | ALA5098688 | A | Volume of distribution in Han-wistar rat at 1.5 umol/kg, iv | Rattus norvegicus | 17 | assay format | Scientific Literature | ||
19. | ALA5098689 | A | Clearance in Han-wistar rat at 1.5 umol/kg, iv | Rattus norvegicus | 17 | assay format | Scientific Literature | ||
20. | ALA5098690 | A | Terminal half life in Han-wistar rat at 1.5 umol/kg, iv | Rattus norvegicus | 17 | assay format | Scientific Literature |