#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA5161737	B	Inhibition of MT2A in MTAP-null human HCT-116 cells after 72 hrs by LC-MS/MS analysis	Homo sapiens	13		cell-based format	Scientific Literature
2.	ALA5161738	B	Inhibition of MT2A in MTAP-null human HCT-116 cells after 72 hrs by LC-MS/MS analysis relative to control	Homo sapiens	13		cell-based format	Scientific Literature
3.	ALA5161739	A	Transactivation of human PXR transfected in HepG2 cells assessed as CYP450 induction by measuring fold activation at 10 uM by luciferase reporter gene assay	Homo sapiens	13		cell-based format	Scientific Literature
4.	ALA5161740	A	Permeability across apical to basolateral membrane in human Caco-2 cells	Homo sapiens	11		cell-based format	Scientific Literature
5.	ALA5161741	A	Efflux ratio of permeability in human Caco-2 cells	Homo sapiens	11		cell-based format	Scientific Literature
6.	ALA5161742	A	Ratio of drug concentration in brain to plasma of mouse at 10 mg/kg, po measured at 1 to 4 hrs post dose	Mus musculus	10		organism-based format	Scientific Literature
7.	ALA5161743	A	Intrinsic clearance in mouse assessed as hepatic extraction ratio at 10 mg/kg, po or 1 mg/kg, iv	Mus musculus	3		organism-based format	Scientific Literature
8.	ALA5161744	A	Volume of distribution at steady state in mouse at 10 mg/kg, po or 1 mg/kg, iv	Mus musculus	3		organism-based format	Scientific Literature
9.	ALA5161745	A	MRT in mouse at 10 mg/kg, po or 1 mg/kg, iv	Mus musculus	3		organism-based format	Scientific Literature
10.	ALA5161746	A	Cmax in mouse at 10 mg/kg, po or 1 mg/kg, iv	Mus musculus	3		organism-based format	Scientific Literature
11.	ALA5161747	A	AUC (0 to 24 hrs) in mouse at 10 mg/kg, po or 1 mg/kg, iv	Mus musculus	3		organism-based format	Scientific Literature
12.	ALA5161750	A	Protein binding in mouse plasma assessed as unbound fraction by ultracentrifugation method	Mus musculus	3		cell-free format	Scientific Literature
13.	ALA5161751	F	Invivo inhibition of MAT2A in human HCT116-MTAP null cells xenografted po dosed nu/nu mouse model assessed as plasma exposure required for reduction in tumor SAM level	Mus musculus	3		organism-based format	Scientific Literature
14.	ALA5161752	F	Invivo inhibition of MAT2A in human HCT116-MTAP null cells xenografted po dosed nu/nu mouse model assessed as plasma exposure required for reduction in brain SAM level	Mus musculus	3		organism-based format	Scientific Literature
15.	ALA5161753	T	Toxicity in nu/nu mouse tumor model xenografted with human HCT116-MTAP null cells assessed as tolerability	Mus musculus	1		assay format	Scientific Literature
16.	ALA5161754	F	Antitumor activity against human HCT116-MTAP null cells xenografted in nu/nu mouse assessed as tumor growth inhibition	Mus musculus	1		cell-based format	Scientific Literature
17.	ALA5161755	T	Toxicity in nu/nu mouse tumor model xenografted with human HCT116-MTAP null cells assessed as body weight loss at 3 to 30 mg/kg, po	Mus musculus	1		organism-based format	Scientific Literature
18.	ALA5161767	F	Inhibition of MAT2A in human HCT116-MTAP null cells xenografted in nu/nu mouse model assessed as reduction in tumor SAM level by measuring EACU50 (0 to 12 hrs) at 0.3 to 10 mg/kg, po administered 2 times QD or 0.3 to 3 mg/kg, po administered 3 times BID and measured upto 24 hrs post last dose	Mus musculus	1		organism-based format	Scientific Literature
19.	ALA5161768	F	Inhibition of MAT2A in human HCT116-MTAP null cells xenografted in nu/nu mouse model assessed as reduction in brain SAM level by measuring EACU50 (0 to 12 hrs) at 0.3 to 10 mg/kg, po administered 2 times QD or 0.3 to 3 mg/kg, po administered 3 times BID and measured upto 24 hrs post last dose	Mus musculus	1		organism-based format	Scientific Literature
20.	ALA5161769	F	Ratio of free plasma IC50 for inhibition of MAT2A in human HCT116-MTAP null cells xenografted po dosed nu/nu mouse model assessed as reduction in tumor SAM level to free plasma IC50 for inhibition of MAT2A in human HCT116-MTAP null cells xenografted po dosed nu/nu mouse model assessed as reduction in brain SAM level	Mus musculus	3		organism-based format	Scientific Literature