| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149459 | B | Induction of recombinant human CD137 assessed as increase in fold change in EC50 incubated for 1 hrs by luminescence based microplate reader assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA5149460 | B | Induction of recombinant human CD137 assessed as increase in fold change in Emax incubated for 1 hrs by luminescence based microplate reader assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA5149462 | F | Antiinflammatory activity in human PBMC stimulated with anti-CD3-mediated CD137 expression in cocultured with HTI376 cell line assessed as increase in secretion of IFN gamma incubated for 48 hrs by Luminex assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA5149463 | F | Antiinflammatory activity in human PBMC stimulated with anti-CD3-mediated CD137 expression in cocultured with HTI376 cell line assessed as increase in secretion of IL2 incubated for 48 hrs by Luminex assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5149464 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA5149465 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 7. | ALA5149466 | P | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5149468 | F | Antitumor activity against human CT26 cells expressed in CD137 transfected in BALB/c mouse at 1mg/kg, qd | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5149469 | F | Antitumor activity against human CT26 cells expressed in CD137 transfected in BALB/c mouse at 5 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5149470 | A | Plasma clearance in Cynomolgus monkey at 1 mg/kg, iv administered for 30 min by LC-MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5149471 | A | Volume of distribution at steady state in Cynomolgus monkey at 1 mg/kg, iv administered for 30 min by LC-MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5149472 | A | Half life in Cynomolgus monkey at 1 mg/kg, iv administered for 30 min by LC-MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5149475 | B | Agonist activity at human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene assessed as fold change in EC50 at 1:1 Nectin-4/CD137 ratio measured after 6 hrs by HT1376/CD137 reporter co-culture assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5149476 | B | Agonist activity at human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene assessed as fold change in Emax at 1:1 Nectin-4/CD137 ratio measured after 6 hrs by HT1376/CD137 reporter co-culture assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!