| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5153127 | F | Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation at 100 nM incubated in presence of IBMX by cAMP-glo assay relative to control | Homo sapiens | 50 | ALA5150046 | cell-based format | Scientific Literature | |
| 2. | ALA5153128 | F | Antagonist activity at P2Y14R (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated in presence of IBMX by cAMP-glo assay | Homo sapiens | 50 | ALA5150046 | cell-based format | Scientific Literature | |
| 3. | ALA5153129 | B | Inhibition of fluorescent antagonist binding to human P2Y14R expressed in HEK293 cells at 3 uM preincubated for 30 mins followed by 4-(4-(1-(4-(4-(3-(3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thioureido)butanamido)butanoyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid addition and measured after 30 mins by flow cytometry analysis | Homo sapiens | 1 | ALA5150046 | cell-based format | Scientific Literature | |
| 4. | ALA5153134 | P | Aqueous solubility of the compound in double distilled water at pH 7 incubated for 24 hrs by UV-3000 absorption spectrometry analysis | 3 | ALA5150046 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA5153135 | P | Aqueous solubility of the compound in simulated gastric fluid without pepsin at pH 1.2 incubated for 24 hrs by UV-3000 absorption spectrometry analysis | 3 | ALA5150046 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA5153136 | P | Aqueous solubility of the compound in simulated intestinal fluid without trypsin at pH 6.8 incubated for 24 hrs by UV-3000 absorption spectrometry analysis | 3 | ALA5150046 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA5153137 | P | Aqueous solubility of the compound in PBS at pH 7.4 incubated for 24 hrs by UV-3000 absorption spectrometry analysis | 3 | ALA5150046 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA5153138 | A | Metabolic stability in human liver microsomes assessed as elimination rate constant at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 9. | ALA5153139 | A | Metabolic stability in human liver microsomes assessed as half life at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA5150046 | microsome format | Scientific Literature | |
| 10. | ALA5153140 | A | Metabolic stability in human liver microsomes assessed as intrinsic permeability at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 11. | ALA5153141 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 12. | ALA5153142 | A | Metabolic stability in rat liver microsomes assessed as elimination rate constant at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 13. | ALA5153143 | A | Metabolic stability in rat liver microsomes assessed as half life at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 14. | ALA5153144 | A | Metabolic stability in rat liver microsomes assessed as intrinsic permeability at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 15. | ALA5153145 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 2 ug/ml preincubated for 5 mins followed by NADPH addition and measured upto 45 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5150046 | microsome format | Scientific Literature | |
| 16. | ALA5153146 | A | Half life in Sprague-Dawley rat at 2.5 mg/kg, iv measured for 24 hrs | Rattus norvegicus | 1 | ALA5150046 | organism-based format | Scientific Literature | |
| 17. | ALA5153147 | A | AUC (0 to infinity) in Sprague-Dawley rat at 2.5 mg/kg, iv measured for 24 hrs | Rattus norvegicus | 1 | ALA5150046 | organism-based format | Scientific Literature | |
| 18. | ALA5153148 | A | Clearance in Sprague-Dawley rat at 2.5 mg/kg, iv measured for 24 hrs | Rattus norvegicus | 1 | ALA5150046 | organism-based format | Scientific Literature | |
| 19. | ALA5153149 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured for 24 hrs | Rattus norvegicus | 1 | ALA5150046 | organism-based format | Scientific Literature | |
| 20. | ALA5153150 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po measured for 24 hrs | Rattus norvegicus | 1 | ALA5150046 | organism-based format | Scientific Literature |
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