| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5163165 | F | Positive allosteric modulator activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of GLP-1(7-36)NH2 induced cAMP accumulation at 10 uM preincubated for 15 mins followed by GLP-1(7-36)NH2 addition and measured after 15 mins relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 2. | ALA5163166 | F | Invivo positive allosteric modulator activity at GLP-1R in 12 hrs fasted Wistar rat assessed as reduction in time spend in hyperglycemia at 1 mg/kg, ip administered 30 mins prior to glucose load injection and measured upto 120 mins | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5163167 | F | Invivo positive allosteric modulator activity at GLP-1R in 12 hrs fasted Wistar rat assessed as potentiation of exendin-4 induced feeding suppression at 1 ug/kg, icv measured upto 240 mins post injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA5163168 | B | Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion at 1 uM incubated for 30 mins in presence of 15 mM of glucose by ELISA | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA5163169 | F | Positive allosteric modulator activity at human GLP-1R expressed in HEK293 cells assessed as potentiation of GLP-1(7-36)NH2 induced cAMP accumulation at 0.1 nM preincubated for 15 mins followed by GLP-1(7-36)NH2 addition and measured after 15 mins relative to GLP-1 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5163170 | B | Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion incubated for 30 mins in presence of high glucose condition by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5163171 | B | Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion incubated for 30 mins in presence of 0.2 nM of GLP-1 by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5163172 | B | Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion at 0.1 nM incubated for 30 mins in presence of exendin(9-39)NH2 by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5163173 | A | Tmax in Sprague-Dawley rat plasma at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5163174 | A | Unbound plasma concentration in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5163175 | A | Cmax in Sprague-Dawley rat plasma at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5163176 | A | AUC (0 to t) in Sprague-Dawley rat plasma at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5163177 | A | AUC (0 to t) in Sprague-Dawley rat plasma at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5163178 | A | AUC (0 to infinity) in Sprague-Dawley rat plasma at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5163179 | A | AUC (0 to infinity) in Sprague-Dawley rat plasma at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5163180 | A | Half life in Sprague-Dawley rat plasma at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5163181 | A | Half life in Sprague-Dawley rat plasma at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5163182 | A | Clearance in Sprague-Dawley rat plasma at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5163183 | A | Volume of distribution in Sprague-Dawley rat plasma at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5163184 | A | Oral bioavailability in Sprague-Dawley rat plasma at 10 mg/kg measured upto 24 hrs by LC-MS/MS method | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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