# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5107733 | Binding | Inhibition of HDAC3-SMRT (unknown origin) using Boc-(Ac)Lys-AMC as substrate preincubated with compound for 1 hrs followed by substrate addition and measured after 1 hrs by fluorescent assay | Homo sapiens | 5 | ALA5104222 | assay format | Scientific Literature | |
2. | ALA5107736 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
3. | ALA5107737 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
4. | ALA5107739 | Binding | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC3 degradation at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
5. | ALA5107741 | Binding | Inhibition of class I HDAC in human HCT-116 cells nucleus extract assessed as increase in H3K56 acetylation level at 0.1 to 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | subcellular format | Scientific Literature | |
6. | ALA5107742 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
7. | ALA5107743 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
8. | ALA5107744 | Binding | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
9. | ALA5107749 | Binding | PROTAC activity at VHL/HDAC1 in human HCT-116 cells assessed as induction of HDAC1 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
10. | ALA5107750 | Binding | PROTAC activity at VHL/HDAC2 in human HCT-116 cells assessed as induction of HDAC2 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA5104222 | cell-based format | Scientific Literature | |
11. | ALA5107751 | Binding | PROTAC activity at VHL/HDAC3 in human HCT-116 cells assessed as induction of HDAC3 degradation by measuring maximum efficacy at 10 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA5104222 | cell-based format | Scientific Literature | |
12. | ALA5107787 | Binding | Inhibition of HDAC1-CoREST-LSD1 (unknown origin) using Boc-(Ac)Lys-AMC as substrate preincubated with compound for 1 hrs followed by substrate addition and measured after 1 hrs by fluorescent assay | Homo sapiens | 5 | ALA5104222 | assay format | Scientific Literature | |
13. | ALA5107788 | Binding | Inhibition of HDAC2-CoREST-LSD1 (unknown origin) using Boc-(Ac)Lys-AMC as substrate preincubated with compound for 1 hrs followed by substrate addition and measured after 1 hrs by fluorescent assay | Homo sapiens | 5 | ALA5104222 | assay format | Scientific Literature |