# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5164911 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse J774.A1 cells assessed as reduction in pyroptosis at 10 uM pretreated for 4 hrs with LPS and for 30 mins with compound prior to ATP addition and measured after 30 mins by PI/Hoechst33342 staining based analysis | Mus musculus | 33 | cell-based format | Scientific Literature | ||
2. | ALA5164912 | T | Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
3. | ALA5164913 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 3 hrs with LPS and for 30 mins with compound prior to nigericin addition and measured after 30 mins by ELISA | Mus musculus | 10 | cell-based format | Scientific Literature |