# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5129798 | A | Metabolic stability in rat lung S9 fraction assessed as half life at 1 uM measured after 0 to 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA5126603 | subcellular format | Scientific Literature | |
2. | ALA5129799 | B | Displacement of [3H]-methylscopolamine from human muscarinic M3 receptor expressed in CHO-K1 cell membrane measured after 2 hr by Cheng-prusoff equation analysis | Homo sapiens | 27 | ALA5126603 | cell membrane format | Scientific Literature | |
3. | ALA5129800 | B | Displacement of 125I-cyanopindolol from human beta2 adrenoceptor expressed in CHO-K1 cell membrane measured after 1 hr by Cheng-prusoff equation analysis | Homo sapiens | 10 | ALA5126603 | cell membrane format | Scientific Literature | |
4. | ALA5129806 | A | Metabolic stability in human lung S9 fraction assessed as half life at 1 uM measured after 0 to 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 8 | ALA5126603 | subcellular format | Scientific Literature | |
5. | ALA5129807 | A | Metabolic stability in Dunkin-Hartley guinea pig lung S9 fraction assessed as half life at 1 uM measured after 0 to 60 mins in presence of NADPH by LC-MS/MS analysis | Cavia porcellus | 4 | ALA5126603 | subcellular format | Scientific Literature | |
6. | ALA5129814 | A | Metabolic stability in human plasma assessed as half life at 5 uM measured upto 120 mins by LC-MS/MS analysis | Homo sapiens | 8 | ALA5126603 | cell-free format | Scientific Literature | |
7. | ALA5129815 | A | Metabolic stability in rat plasma assessed as half life at 5 uM measured upto 120 mins by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA5126603 | cell-free format | Scientific Literature | |
8. | ALA5129816 | A | Metabolic stability in Dunkin-Hartley guinea pig plasma assessed as half life at 5 uM measured upto 120 mins by LC-MS/MS analysis | Cavia porcellus | 6 | ALA5126603 | cell-free format | Scientific Literature | |
9. | ALA5129835 | F | Invivo antagonist activity at muscarinic M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 nmol/Kg, IT(Intratracheal) measured after 1 hr in presence of ICI-118551 by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
10. | ALA5129836 | F | Invivo agonist activity at beta-2 adrenoceptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of histamine-induced bronchoconstriction at 3 nmol/Kg, IT(Intratracheal) measured after 1 hr by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
11. | ALA5129837 | F | Bifunctional antagonist activity at muscarinic M3 receptor /agonist activity at beta-2 adrenoceptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 nmol/Kg, IT(Intratracheal) measured after 1 hr by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
12. | ALA5129838 | F | Invivo antagonist activity at muscarinic M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 nmol/Kg, IT(Intratracheal) measured after 24 hr in presence of ICI-118551 by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
13. | ALA5129839 | F | Invivo agonist activity at beta-2 adrenoceptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of histamine-induced bronchoconstriction at 3 nmol/Kg, IT(Intratracheal) measured after 24 hr by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
14. | ALA5129840 | F | Bifunctional antagonist activity at muscarinic M3 receptor /agonist activity at beta-2 adrenoceptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of acetylcholine-induced bronchoconstriction at 3 nmol/Kg, IT(Intratracheal) measured after 24 hr by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
15. | ALA5129841 | F | Invivo antagonist activity at muscarinic M3 receptor activity in Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol induced contraction in presence of propranolol | Cavia porcellus | 8 | ALA5126603 | tissue-based format | Scientific Literature | |
16. | ALA5129842 | F | Invivo bifunctional antagonist activity at muscarinic M3 receptor /agonist activity at beta-2 adrenoceptor in Dunkin-Hartley guinea pig trachea assessed as time duration for inhibition of carbachol induced contraction measured upto 4 hrs | Cavia porcellus | 8 | ALA5126603 | tissue-based format | Scientific Literature | |
17. | ALA5129843 | F | Invivo agonist beta2 adrenoceptor activity in Dunkin-Hartley guinea pig trachea assessed as histamine induced contraction | Cavia porcellus | 8 | ALA5126603 | tissue-based format | Scientific Literature | |
18. | ALA5129844 | F | Invivo bifunctional antagonist activity at muscarinic M3 receptor /agonist activity at beta-2 adrenoceptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of carbachol induced contraction | Cavia porcellus | 8 | ALA5126603 | tissue-based format | Scientific Literature | |
19. | ALA5129861 | F | Invivo antagonist activity at muscarinic M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of acetylcholine induced bronchoconstriction at 1 nmol/Kg, IT(Intratracheal) measured after 1 hr in presence of ICI-118551 by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature | |
20. | ALA5129862 | F | Invivo antagonist activity at muscarinic M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of acetylcholine induced bronchoconstriction at 1 nmol/Kg, IT(Intratracheal) measured after 24 hr in presence of ICI-118551 by Konzett-Roessler methodology relative to control | Cavia porcellus | 3 | ALA5126603 | assay format | Scientific Literature |