# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5156677 | Binding | Induction of membrane disruption in multidrug-resistant Acinetobacter baumannii assessed as loss of cell integrity at 16 ug/ml measured after 2 hrs by SEM analysis | Acinetobacter baumannii | 3 | ALA5154678 | subcellular format | Scientific Literature | |
2. | ALA5156678 | Binding | Induction of membrane disruption in methicillin-resistant Staphylococcus aureus BNCC 186335 assessed as loss of cell integrity at 16 ug/ml measured after 2 hrs by SEM analysis | Staphylococcus aureus | 3 | ALA5154678 | subcellular format | Scientific Literature | |
3. | ALA5156679 | Binding | Induction of membrane damage in multidrug-resistant Acinetobacter baumannii assessed as concentration of stained cells incubated for 2 hrs by propidium iodide staining based flow cytometer assay | Acinetobacter baumannii | 3 | ALA5154678 | subcellular format | Scientific Literature | |
4. | ALA5156680 | Binding | Induction of membrane damage in methicillin-resistant Staphylococcus aureus BNCC 186335 assessed as concentration of stained cells incubated for 2 hrs by propidium iodide staining based flow cytometer assay | Staphylococcus aureus | 3 | ALA5154678 | subcellular format | Scientific Literature | |
5. | ALA5156681 | Functional | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Staphylococcus aureus | 20 | ALA5154678 | organism-based format | Scientific Literature | |
6. | ALA5156682 | Functional | Antibacterial activity against Staphylococcus aureus BNCC 186335 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Staphylococcus aureus | 20 | ALA5154678 | organism-based format | Scientific Literature | |
7. | ALA5156683 | Functional | Antibacterial activity against Listeria monocytogenes assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Listeria monocytogenes | 20 | ALA5154678 | organism-based format | Scientific Literature | |
8. | ALA5156685 | Functional | Antibacterial activity against Pseudomonas aeruginosa BNCC 125486 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Pseudomonas aeruginosa | 20 | ALA5154678 | organism-based format | Scientific Literature | |
9. | ALA5156686 | Functional | Antibacterial activity against Escherichia coli BNCC 133264 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Escherichia coli | 20 | ALA5154678 | organism-based format | Scientific Literature | |
10. | ALA5156687 | Functional | Antibacterial activity against cephalosporin-resistant Escherichia coli BNCC 133264 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Escherichia coli | 20 | ALA5154678 | organism-based format | Scientific Literature | |
11. | ALA5156688 | Toxicity | Hemolytic activity against human RBC assessed as concentration required to cause 10% hemolysis | Homo sapiens | 18 | ALA5154678 | cell-based format | Scientific Literature | |
12. | ALA5156691 | Functional | Antibacterial activity against methicillin-resistant Staphylococcus aureus BNCC 186335 assessed as inhibition of bacterial growth incubated for 4 hrs in presence of 25% plasma by broth microdilution method | Staphylococcus aureus | 6 | ALA5154678 | organism-based format | Scientific Literature | |
13. | ALA5156692 | ADME | Stability in human plasma assessed as half life measured after 24 hrs by HPLC analysis | Homo sapiens | 3 | ALA5154678 | cell-free format | Scientific Literature | |
14. | ALA5156693 | Toxicity | Cytotoxicity against human HEK293T cells assessed as cell survival rate at 128 ug/ml incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA5154678 | cell-based format | Scientific Literature | |
15. | ALA5156694 | Functional | Antibacterial activity against multidrug-resistant Enterococcus faecium assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Enterococcus faecium | 3 | ALA5154678 | organism-based format | Scientific Literature | |
16. | ALA5156695 | Functional | Antibacterial activity against multidrug-resistant Staphylococcus aureus BNCC 186335 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Staphylococcus aureus | 3 | ALA5154678 | organism-based format | Scientific Literature | |
17. | ALA5156696 | Functional | Antibacterial activity against multidrug-resistant Klebsiella pneumoniae assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Klebsiella pneumoniae | 3 | ALA5154678 | organism-based format | Scientific Literature | |
18. | ALA5156697 | Functional | Antibacterial activity against multidrug-resistant Acinetobacter baumannii assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Acinetobacter baumannii | 3 | ALA5154678 | organism-based format | Scientific Literature | |
19. | ALA5156698 | Functional | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa BNCC 125486 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Pseudomonas aeruginosa | 3 | ALA5154678 | organism-based format | Scientific Literature | |
20. | ALA5156699 | Functional | Antibacterial activity against multidrug-resistant Escherichia coli BNCC 133264 assessed as inhibition of bacterial growth incubated for 16 hrs by broth microdilution method | Escherichia coli | 3 | ALA5154678 | organism-based format | Scientific Literature |