# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5151504 | B | Inhibition of PI3Kdelta (unknown origin) | Homo sapiens | 19 | ALA5149992 | single protein format | Scientific Literature | |
2. | ALA5151505 | B | Inhibition of PI3Kgamma (unknown origin) | Homo sapiens | 17 | ALA5149992 | single protein format | Scientific Literature | |
3. | ALA5151506 | B | Inhibition of PI3Kalpha (unknown origin) | Homo sapiens | 11 | ALA5149992 | single protein format | Scientific Literature | |
4. | ALA5151507 | B | Inhibition of PI3Kbeta (unknown origin) | Homo sapiens | 12 | ALA5149992 | single protein format | Scientific Literature | |
5. | ALA5151508 | A | Metabolic stability in human liver microsome assessed as half life at 10 uM in presence of NADPH incubated up to 60 hrs | Homo sapiens | 18 | ALA5149992 | microsome format | Scientific Literature | |
6. | ALA5151509 | A | Metabolic stability in human liver microsome assessed as intrinsic clearance at 10 uM in presence of NADPH incubated up to 60 hrs | Homo sapiens | 18 | ALA5149992 | microsome format | Scientific Literature | |
7. | ALA5151512 | B | Inhibition of PI3Kalpha in human SK-OV-3 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 mins | Homo sapiens | 2 | ALA5149992 | cell-based format | Scientific Literature | |
8. | ALA5151513 | B | Inhibition of PI3Kbeta in human 786-0 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 mins | Homo sapiens | 2 | ALA5149992 | cell-based format | Scientific Literature | |
9. | ALA5151514 | B | Inhibition of PI3Kgamma in c5a-stimulated mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 mins | Mus musculus | 2 | ALA5149992 | cell-based format | Scientific Literature | |
10. | ALA5151515 | B | Inhibition of PI3Kdelta in anti-IgM-stimulated human Raji cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 mins | Homo sapiens | 2 | ALA5149992 | cell-based format | Scientific Literature | |
11. | ALA5151516 | B | Inhibition of PI3Kdelta in anti-FceRI-stimulated human Basophil cells degranulation incubated for 30 mins | Homo sapiens | 2 | ALA5149992 | cell-based format | Scientific Literature | |
12. | ALA5151517 | B | Inhibition of PI3Kdelta in anti-IgM-stimulated human whole blood B cell degranulation incubated for 60 mins by flow cytometry | Homo sapiens | 2 | ALA5149992 | tissue-based format | Scientific Literature | |
13. | ALA5151518 | B | Inhibition of PI3Kdelta in conA-stimulated primary human T cell proliferation incubated for 1 hr by CellTiter-glo luminescent assay | Homo sapiens | 2 | ALA5149992 | cell-based format | Scientific Literature | |
14. | ALA5151519 | T | Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Rattus norvegicus | 1 | ALA5149992 | cell-based format | Scientific Literature | |
15. | ALA5151520 | T | Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Mus musculus | 1 | ALA5149992 | cell-based format | Scientific Literature | |
16. | ALA5151521 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5149992 | cell-based format | Scientific Literature | |
17. | ALA5151522 | T | Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 1 | ALA5149992 | cell-based format | Scientific Literature | |
18. | ALA5151523 | A | Elimination half life in Sprague-Dawley rat at 5 mg/kg, po incubated for 5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5149992 | organism-based format | Scientific Literature | |
19. | ALA5151524 | A | Elimination half life in Sprague-Dawley rat at 5 mg/kg, iv incubated for 5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5149992 | organism-based format | Scientific Literature | |
20. | ALA5151525 | A | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, po incubated for 5 to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5149992 | organism-based format | Scientific Literature |