| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5146487 | F | Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA5146488 | B | Inhibition of PDE10A (unknown origin) preincubated for 20 mins followed by substrate addition and measured after 1 hr by PEDlight AMP detection reagent based luminescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 3. | ALA5146489 | F | Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of cAMP production incubated for 40 mins by TR-FRET assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA5146493 | B | Displacement of [3H]-8-OH-DAPT from human 5-HT1A receptor expressed in CHO-K1 cells membrane by scintillation counter analysis | Homo sapiens | 24 | cell membrane format | Scientific Literature | ||
| 5. | ALA5146494 | B | Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis | Homo sapiens | 24 | cell membrane format | Scientific Literature | ||
| 6. | ALA5146496 | B | Inhibition of PDE10A (unknown origin) at 10 uM preincubated for 20 mins followed by substrate addition and measured after 1 hr by PEDlight AMP detection reagent based luminescence assay relative to control | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 7. | ALA5146500 | F | Agonist activity at human 5-HT1A receptor expressed in human U2OS cells assessed as beta-arrestin recruitment by measuring maximal efficacy at 0.0001 to 10 uM incubated for 5 hrs by Tango assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA5146502 | F | Partial agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as ERK1/2 phosphorylation by measuring maximal efficacy at 0.0001 to 10 uM incubated for 15 mins by Alpha LISA assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA5146504 | F | Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA5146505 | F | Bias factor, ratio of agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as ERK1/2 phosphorylation at 0.0001 to 10 uM to agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment at 0.0001 to 10 uM | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA5146507 | B | Binding affinity to 5HT-2A receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA5146508 | B | Inhibition of 5-HT6 receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA5146509 | B | Binding affinity to dopamine D2 receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 14. | ALA5146510 | B | Binding affinity to adrenergic alpha 1 receptor (unknown origin) | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 15. | ALA5146511 | F | Antidepressant activity in Swiss albino mouse assessed as reduction in immobility time at 0.625 to 5 mg/kg, ip measured for last 4 mins of 6 mins test by forced swim test | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 16. | ALA5146515 | F | Antidepressant activity in Swiss albino mouse assessed as reduction in immobility time at 1.25 to 2.5 mg/kg, ip measured for last 4 mins of 6 mins test by forced swim test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5146521 | F | Pro-cognitive activity in MK-801-induced memory impaired Wistar rat assessed as recognition of novel location by measuring discrimination index at 1 to 3 mg/kg, ip preincubated for 30 mins followed by MK-801 addition for 30 mins prior to T1 phase by novel object location test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5146523 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 19. | ALA5146524 | A | Tmax in mouse plasma at 1.25 mg/kg, ip measured up to 480 mins by LC/ESI-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5146526 | A | Cmax in mouse plasma at 1.25 mg/kg, ip measured up to 480 mins by LC/ESI-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!