# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5099566 | Functional | Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 30 mins by methylene blue staining based analysis | Homo sapiens | 6 | ALA5096224 | cell-based format | Scientific Literature | |
2. | ALA5099567 | Functional | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 30 mins by methylene blue staining based analysis | Homo sapiens | 6 | ALA5096224 | cell-based format | Scientific Literature | |
3. | ALA5099572 | Functional | Cytotoxicity against human NCI-H522 cells assessed as reduction in cell survival at 1 to 5 uM incubated for 3 days in presence of ferroptosis inhibitor, liproxstatin-1 by methylene blue staining based analysis | Homo sapiens | 6 | ALA5096224 | cell-based format | Scientific Literature | |
4. | ALA5099575 | Toxicity | Cytotoxicity against human WI-38 cells assessed as reduction in cell survival incubated for 30 mins by methylene blue staining based analysis | Homo sapiens | 3 | ALA5096224 | cell-based format | Scientific Literature | |
5. | ALA5099576 | Toxicity | Ratio of IC50 for cytotoxicity against human WI-38 cells to IC50 for cytotoxicity against human NCI-H522 | Homo sapiens | 3 | ALA5096224 | cell-based format | Scientific Literature | |
6. | ALA5099577 | Toxicity | Ratio of IC50 for cytotoxicity against human RPE cells to IC50 for cytotoxicity against human HCT-116 cells | Homo sapiens | 3 | ALA5096224 | cell-based format | Scientific Literature | |
7. | ALA5099581 | Toxicity | Neurotoxicity in human SH-SY5Y cells assessed as decrease in cell viability at 2.32 uM incubated for 3 days | Homo sapiens | 1 | ALA5096224 | cell-based format | Scientific Literature | |
8. | ALA5099583 | Functional | Induction of ferroptosis in human NCI-H522 cells assessed as induction of lipid peroxidase accumulation at 10 uM incubated for 6 hrs by C11-BODIPY-581/591 staining based flow cytometry analysis | Homo sapiens | 1 | ALA5096224 | cell-based format | Scientific Literature | |
9. | ALA5099584 | Functional | Induction of ferroptosis in human NCI-H522 cells assessed as induction of lipid peroxidase accumulation at 10 uM incubated for 6 hrs in presence of Lipoxstatin-1 by C11-BODIPY-581/591 staining based flow cytometry analysis | Homo sapiens | 1 | ALA5096224 | cell-based format | Scientific Literature | |
10. | ALA5099589 | Binding | Inhibition of HDAC in human NCI-H522 cells assessed as increase in acetylation of H3 at 2.5 to 10 uM measured for 3 days by Western blot analysis | Homo sapiens | 3 | ALA5096224 | cell-based format | Scientific Literature | |
11. | ALA5099590 | Binding | Inhibition of HDAC6 in human NCI-H522 cells assessed as increase in acetylation of tubulin at 2.5 to 10 uM measured for 3 days by Western blot analysis | Homo sapiens | 3 | ALA5096224 | cell-based format | Scientific Literature | |
12. | ALA5099593 | Binding | Inhibition of full length his6/FLAG-tagged human recombinant HDAC1(1 to 482 residues) expressed in Sf9 insect cells | Homo sapiens | 12 | ALA5096224 | cell-based format | Scientific Literature | |
13. | ALA5099594 | Binding | Inhibition of full length C-terminal his6-tagged human recombinant HDAC2 (1 to 488 residues) | Homo sapiens | 12 | ALA5096224 | single protein format | Scientific Literature | |
14. | ALA5099595 | Binding | Inhibition of full length C-terminal FLAG-tagged human recombinant HDAC6 expressed inSf9 insect cells | Homo sapiens | 12 | ALA5096224 | cell-based format | Scientific Literature | |
15. | ALA5099596 | Binding | Inhibition of full length C-terminal his6/FLAG-tagged human recombinant HDAC3 (1 to 2383 residues) expressed in Sf9 insect cells | Homo sapiens | 12 | ALA5096224 | cell-based format | Scientific Literature | |
16. | ALA5099597 | Binding | Inhibition of full length C-terminal his-tagged human recombinant HDAC8 expressed in Sf9 insect cells | Homo sapiens | 12 | ALA5096224 | cell-based format | Scientific Literature | |
17. | ALA5099601 | Functional | Induction of ferroptosis in human NCI-H522 cells assessed as viability at 5 uM incubated at 0.2 to 10.2 hrs by microscopic analysis | Homo sapiens | 1 | ALA5096224 | cell-based format | Scientific Literature | |
18. | ALA5099602 | Functional | Induction of ferroptosis in human NCI-H522 cells assessed as viability at 5 uM incubated after 60 hrs hrs in presence of Liproxstatin-1 by microscopic analysis | Homo sapiens | 1 | ALA5096224 | cell-based format | Scientific Literature | |
19. | ALA5099603 | Functional | Induction of cell cycle arrest in human NCI-H522 cells assessed as accumulation at S phase 5 uM incubated for 24 to 72 hrs by PI staining based flow cytometric analysis | Homo sapiens | 2 | ALA5096224 | cell-based format | Scientific Literature | |
20. | ALA5099604 | Functional | Induction of cell cycle arrest in human NCI-H522 cells assessed as accumulation at G1 phase 5 uM incubated for 24 to 72 hrs by PI staining based flow cytometric analysis | Homo sapiens | 2 | ALA5096224 | cell-based format | Scientific Literature |