| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5120624 | B | Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-2 stimulation for 15 mins by FACS method | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 2. | ALA5120628 | F | Inhibition of IL-2 stimulated IFN-gamma production in BALB/c mouse at 40 mg/kg, po pretreated for 30 mins followed by IL-2 stimulation and measured after 4 hrs by ELISA | Mus musculus | 15 | organism-based format | Scientific Literature | ||
| 3. | ALA5120629 | T | Inhibition of JAK2 signaling pathway in human CHEP cells assessed as inhibition of EPO-induced cell survival preincubated for 1 hr followed by EPO addition and measured after 48 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA5120630 | B | Selectivity ratio of IC50 for inhibition of JAK2 signaling pathway in EPO-stimulated human CHEP cells to IC50 for inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 5. | ALA5120631 | F | Inhibition of IL-2 stimulated IFN-gamma production in BALB/c mouse at 5 mg/kg, po pretreated for 30 mins followed by IL-2 stimulation and measured after 4 hrs by ELISA | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 6. | ALA5120632 | A | Inhibition of CYP3A4 (unknown origin) in absence of NADPH | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 7. | ALA5120633 | A | Inhibition of CYP3A4 (unknown origin) in presence of NADPH | Homo sapiens | 11 | single protein format | Scientific Literature |
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