| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5215271 | F | Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 2. | ALA5215272 | F | Agonist activity at human GLP-1R expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assay relative to control | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 3. | ALA5215273 | F | Agonist activity at human GCGR expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA5215274 | F | Agonist activity at human GCGR expressed in HEK293 cells incubated for 30 mins and assessed as increase in cAMP accumulation measured by HTRF assay relative to control | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 5. | ALA5215275 | F | In vivo agonist activity at GLP-1R in C57BL/6J DIO mouse at 10 nmol/kg, ip administered at -30 mins in presence of GLP1-R antagonist Jant-4 administered at 1 umol/kg, ip at -60 mins and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA5215276 | F | In vivo agonist activity at GCGR in streptozotocin induced diabetic mouse model of C57BL/6J at 10 nmol/kg, ip administered at 0 mins in presence of GCGR antagonist LY240902 administered at 1 umol/kg, ip at -15 mins and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5215277 | F | Antidiabetic activity in DIO mouse assessed as reduction in blood glucose at 10 nmol/kg, ip pretreated with compound and followed by glucose challenge and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5215280 | F | Antidiabetic activity in DIO mouse assessed as reduction in plasma insulin level at 10 nmol/kg, ip pretreated with compound and followed by glucose challenge and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5215281 | F | Antidiabetic activity in db/db mouse assessed as reduction in blood glucose at 10 nmol/kg, ip pretreated with compound and followed by glucose challenge and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5215284 | F | Antidiabetic activity in db/db mouse assessed as reduction in plasma insulin level at 10 nmol/kg, ip pretreated with compound and followed by glucose challenge and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5215287 | F | Antidiabetic activity in overnight fasted male C57BL/6J mouse at 10 nmol/kg, ip administered at -30 mins in presence of GLP1-R antagonist Jant-4 administered at 1 umol/kg, ip at -60 mins and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5215288 | F | Antidiabetic activity in overnight fasted male C57BL/6J mouse at 10 nmol/kg, ip administered at -30 mins and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5215289 | F | Antidiabetic activity in 2 hrs fasted male C57BL/6J mouse at 10 to 30 nmol/kg, ip administered at 0 mins in presence of GLP1-R antagonist Jant-4 administered at 1 umol/kg, ip at -60 mins and somatostatin at 10 mg/kg, sc administered at -30 mins and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5215290 | F | Antidiabetic activity in 2 hrs fasted male C57BL/6J mouse at 10 to 30 nmol/kg, ip administered at 0 mins in presence of somatostatin at 10 mg/kg, sc administered at -30 mins and measured by oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5215291 | F | Antidiabetic activity in male DIO mouse assessed as reduction in acute food intake at 10 nmol/kg, sc measured at 0 to 2 hrs post administration | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5215295 | F | Antidiabetic activity in male DIO mouse assessed as reduction in acute food intake at 10 nmol/kg, sc measured at 24 hrs post administration | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5215296 | F | Antidiabetic activity in overnight fasted male C57BL/6J mouse assessed as reduction in acute food intake at 30 nmol/kg, sc administered at -0.5 hrs in presence of GLP1-R antagonist Jant-4 administered at 1 umol/kg, sc at -1 hr | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA5215297 | F | Antidiabetic activity in overnight fasted male C57BL/6J mouse assessed as reduction in acute food intake at 30 nmol/kg, sc administered at -0.5 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA5215298 | F | Antidiabetic activity in overnight fasted male Sprague-Dawley rat assessed as reduction in food intake at 10 nmol/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5215299 | F | Antidiabetic activity in overnight fasted male Sprague-Dawley rat assessed as reduction in food intake at 100 nmol/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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