| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5215461 | F | Invivo Antagonist activity at Maxadilan-induced Sprague-Dawley rat assessed as reduction in Maxadilan-induced blood flow at 0.3 mg/kg,sc measured after 45 mins | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5215465 | B | Antagonist activity at PAC1R in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA5215468 | B | Antagonist activity at PAC1R in rat RG2 cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5215469 | B | Antagonist activity at PAC1R in human SH-SY5Y cells assessed as inhibition of Maxadilan-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5215470 | B | Antagonist activity at PAC1R in rat RG2 cells assessed as inhibition of Maxadilan-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5215471 | A | Half life in Sprague-Dawley rat at 2 mg/kg,iv measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5215472 | A | Cmax in Sprague-Dawley rat at 2 mg/kg,iv measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5215473 | A | AUC (0-infinity) in Sprague-Dawley rat at 2 mg/kg,iv measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5215474 | A | Clearance in Sprague-Dawley rat at 2 mg/kg,iv measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5215475 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg,iv measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5215476 | A | Half life in Sprague-Dawley rat at 10 mg/kg,sc measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5215477 | A | Cmax in Sprague-Dawley rat at 10 mg/kg,sc measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5215478 | A | AUC (0-infinity) in Sprague-Dawley rat at 10 mg/kg,sc measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5215479 | A | Tmax in Sprague-Dawley rat at 10 mg/kg,sc measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5215480 | A | Bioavailability in Sprague-Dawley rat at 10 mg/kg,sc measured upto 6 hrs by LC-MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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