| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5217638 | B | Inhibition of wild type his tagged Escherichia coli K12 MurA at 20 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins by malachite green based microplate reader analysis relative to control | Escherichia coli | 47 | single protein format | Scientific Literature | ||
| 2. | ALA5217639 | B | Inhibition of wild type his tagged Escherichia coli K12 MurA using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins by malachite green based microplate reader analysis | Escherichia coli | 41 | single protein format | Scientific Literature | ||
| 3. | ALA5217640 | B | Inhibition of wild type his tagged Escherichia coli K12 MurB at 20 uM using UNAGEP as substrate preincubated for 15 mins followed by NADPH addition and measured for 2 mins by microplate reader analysis relative to control | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 4. | ALA5217641 | T | Cytotoxicity against human MRC5 cells at upto 100 uM incubated for 24 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5217642 | T | Cytotoxicity against human HepG2 cells at upto 100 uM incubated for 24 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5217643 | F | Antibacterial activity against Staphylococcus aureus Newman assessed as inhibition of bacterial growth incubated for 16 hrs by microplate reader analysis | Staphylococcus aureus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA5217644 | F | Antibacterial activity against Escherichia coli harboring delta tolC efflux defective mutant assessed as inhibition of bacterial growth incubated for 16 hrs by microplate reader analysis | Escherichia coli | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5217645 | F | Antibacterial activity against Escherichia coli harboring delta tolC efflux defective mutant assessed as inhibition of bacterial growth incubated for 16 hrs in presence of 6 ug/ml PMBN by microplate reader analysis (Rvb = >40 microM) | Escherichia coli | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA5217646 | A | Stability in human S9 fractions assessed as degradation at measured after 2 hrs by HPLC-MS analysis | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 10. | ALA5217647 | A | Stability in human S9 fractions assessed as half life at by HPLC-MS analysis | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 11. | ALA5217648 | A | Stability in human plasma assessed as degradation at measured after 4 hrs by HPLC-MS analysis | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 12. | ALA5217649 | A | Stability in human plasma assessed as half life at by HPLC-MS analysis | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 13. | ALA5217650 | A | Stability in Escherichia coli delta tolC bacterial lysate assessed as degradation measured after 4 hrs by HPLC-MS analysis | Escherichia coli | 1 | subcellular format | Scientific Literature | ||
| 14. | ALA5217651 | A | Stability in Escherichia coli delta tolC bacterial lysate assessed as half life by HPLC-MS analysis | Escherichia coli | 1 | subcellular format | Scientific Literature | ||
| 15. | ALA5217652 | B | Inhibition of wild type his tagged Escherichia coli K12 MurA at 0.2 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 15 mins prior to compound addition for 15 mins followed by DTT and PEP addition by dilution assay | Escherichia coli | 2 | single protein format | Scientific Literature | ||
| 16. | ALA5217653 | B | Inhibition of wild type his tagged Escherichia coli K12 MurA at 2 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins by malachite green based microplate reader analysis relative to control | Escherichia coli | 2 | single protein format | Scientific Literature | ||
| 17. | ALA5217654 | B | Inhibition of wild type his tagged Escherichia coli K12 MurA at 2 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins in presence of fosfomycin by malachite green based microplate reader analysis relative to control | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 18. | ALA5217655 | B | Inhibition of wild type his tagged Escherichia coli K12 MurA C115D mutant at 2 uM using UDP-N-acetylglucosamine as substrate in presence of DTT and PEP by microplate reader analysis relative to control | Escherichia coli | 2 | single protein format | Scientific Literature | ||
| 19. | ALA5217656 | B | Inhibition of his tagged Escherichia coli K12 MurA C115D mutant at 2 uM using UDP-N-acetylglucosamine as substrate in presence of DTT, PEP and fosfomycin by microplate reader analysis relative to control | Escherichia coli | 1 | single protein format | Scientific Literature | ||
| 20. | ALA5217657 | B | Uncompetitive inhibition of wild type his tagged Escherichia coli K12 MurA at 2.23 to 3.34 uM using varying concentration of UDP-N-acetylglucosamine as substrate measured after 5 to 30 mins by malachite green assay | Escherichia coli | 1 | single protein format | Scientific Literature |
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