# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5216674 | B | Agonist activity at STING in human THP-1 cells harboring IRF-inducible luciferase reporter construct assessed as fold change in ISG signalling at 20 uM incubated for 12 hrs by Quanti-luc reagent based assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
2. | ALA5216676 | B | Binding affinity to recombinant human STING H232 variant expressed in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 2 mM incubated for 30 mins by SYPRO orange dye based differential scanning fluorimetry assay | Homo sapiens | 18 | assay format | Scientific Literature | ||
3. | ALA5216677 | B | Agonist activity at STING in human THP-1 cells harboring IRF-inducible luciferase reporter construct assessed as increase in ISG signalling incubated for 12 hrs by Quanti-luc reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA5216678 | B | Agonist activity at STING in cGAS knockout human THP-1 cells harboring IRF-inducible luciferase reporter construct assessed as increase in ISG signalling at 20 uM incubated for 12 hrs by Quanti-luc reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA5216679 | B | Agonist activity at STING in STING knockout human THP-1 cells harboring IRF-inducible luciferase reporter construct assessed as increase in ISG signalling at 20 uM incubated for 12 hrs by Quanti-luc reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA5216680 | B | Agonist activity at STING in mouse RAW264.7 cells harboring IRF-inducible luciferase reporter construct assessed as increase in ISG signalling at 20 uM incubated for 12 hrs by Quanti-luc reagent based assay | Mus musculus | 1 | cell-based format | Scientific Literature |