# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5217151 | B | Inhibition of N-terminal His-tagged full length mouse LMW-PTP expressed in Escherichia coli BL21(DE3) by SDS PAGE based mass spectrometry analysis | Mus musculus | 4 | ALA5214960 | assay format | Scientific Literature | |
2. | ALA5217153 | B | Inhibition of His-tagged human LMW-PTP expressed in Escherichia coli BL21 using pNPP as substrate incubated for 10 mins by microplate reader based spectrophotometric analysis | Homo sapiens | 30 | ALA5214960 | assay format | Scientific Literature | |
3. | ALA5217169 | P | Aqueous solubility of compound at pH 6 by HPLC analysis | 8 | ALA5214960 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5217170 | A | Inhibition of human hepatic CYP2D6 using bufuralol HCL as substrate measured after 3 mins by LC-MS analysis relative to control | Homo sapiens | 8 | ALA5214960 | tissue-based format | Scientific Literature | |
5. | ALA5217171 | A | Inhibition of human hepatic CYP2C9 using diclofenac as substrate measured after 10 mins by LC-MS analysis relative to control | Homo sapiens | 8 | ALA5214960 | tissue-based format | Scientific Literature | |
6. | ALA5217172 | A | Inhibition of human hepatic CYP3A4 using midazolam as substrate measured after 3 mins by LC-MS analysis relative to control | Homo sapiens | 8 | ALA5214960 | tissue-based format | Scientific Literature | |
7. | ALA5217173 | A | Metabolic stability in human hepatic microsome at 4 uM measured after 30 mins by LC-MS analysis | Homo sapiens | 8 | ALA5214960 | microsome format | Scientific Literature | |
8. | ALA5217174 | A | Metabolic stability in mouse hepatic microsome at 4 uM measured after 30 mins by LC-MS analysis | Mus musculus | 8 | ALA5214960 | microsome format | Scientific Literature | |
9. | ALA5217175 | A | Metabolic stability in dog hepatic microsome at 4 uM measured after 30 mins by LC-MS analysis | Canis lupus familiaris | 8 | ALA5214960 | microsome format | Scientific Literature | |
10. | ALA5217176 | A | Plasma protein binding in mouse assessed as unbound fraction measured after 4.5 hrs by LC-MS/MS analysis | Mus musculus | 8 | ALA5214960 | cell-free format | Scientific Literature | |
11. | ALA5217177 | A | Apparent permeability in MDCK-MDR1 cells measured after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 8 | ALA5214960 | cell-based format | Scientific Literature | |
12. | ALA5217178 | A | AUC(0 to 8 hrs) in CD-1 mouse plasma at 10 mg/kg, po measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
13. | ALA5217179 | A | AUC(0 to 8 hrs) in CD-1 mouse plasma at 2 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
14. | ALA5217180 | A | Cmax in CD-1 mouse plasma at 10 mg/kg, po measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
15. | ALA5217181 | A | Cmax in CD-1 mouse plasma at 2 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
16. | ALA5217182 | A | Unbound Cmax in plasma of CD-1 mouse at 10 mg/kg, po measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
17. | ALA5217183 | A | Unbound Cmax in plasma of CD-1 mouse at 2 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
18. | ALA5217184 | A | Volume of distribution at steady state in CD-1 mouse plasma at 2 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
19. | ALA5217185 | A | Clearance in CD-1 mouse plasma at 2 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature | |
20. | ALA5217186 | A | Half life in CD-1 mouse plasma at 2 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5214960 | organism-based format | Scientific Literature |