# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5216916 | F | Inhibition of colony formation in human MGC-803 cells at 1 uM incubated for 10 to 15 days by crystal violet staining based assay | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
2. | ALA5216917 | F | Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 6 | ALA5214948 | cell-based format | Scientific Literature | |
3. | ALA5216918 | F | Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured after 72 hrs by CCK-8 assay | Homo sapiens | 6 | ALA5214948 | cell-based format | Scientific Literature | |
4. | ALA5216919 | A | Half life in ICR mouse at 5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5214948 | organism-based format | Scientific Literature | |
5. | ALA5216920 | A | Cmax in ICR mouse at 5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5214948 | organism-based format | Scientific Literature | |
6. | ALA5216921 | A | AUC (0 to t) in ICR mouse at 5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5214948 | organism-based format | Scientific Literature | |
7. | ALA5216922 | A | AUC (0 to infinity) in ICR mouse at 5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5214948 | organism-based format | Scientific Literature | |
8. | ALA5216923 | A | Clearance in ICR mouse at 5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5214948 | organism-based format | Scientific Literature | |
9. | ALA5216924 | A | Volume of distribution at steady state in ICR mouse at 5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA5214948 | organism-based format | Scientific Literature | |
10. | ALA5216925 | B | Binding affinity to full length wild type STAT3-SH2 domain (unknown origin) assessed as association constant by SPR analysis | Homo sapiens | 2 | ALA5214948 | single protein format | Scientific Literature | |
11. | ALA5216926 | B | Binding affinity to full length wild type STAT3-SH2 domain (unknown origin) assessed as equilibrium dissociation constant by SPR analysis | Homo sapiens | 2 | ALA5214948 | single protein format | Scientific Literature | |
12. | ALA5216927 | B | Binding affinity to full length wild type STAT3-SH2 domain (unknown origin) in human MGC-803 cells assessed as thermal stabilization of protein at 37 to 53 degreeC at 5 uM incubated for 3 hrs by cellular thermal shift assay | Homo sapiens | 2 | ALA5214948 | cell-based format | Scientific Literature | |
13. | ALA5216928 | B | Inhibition of STAT3 phosphorylation at Tyr705 residue in human AGS cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
14. | ALA5216929 | B | Inhibition of STAT3 phosphorylation at Tyr705 residue in human MGC-803 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
15. | ALA5216930 | B | Inhibition of STAT3 signaling pathway in human AGS cells assessed as effect on total protein level at 1 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
16. | ALA5216931 | B | Inhibition of STAT3 signaling pathway in human AGS cells assessed as effect on total protein level at 3 to 5 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
17. | ALA5216932 | B | Inhibition of STAT1 phosphorylation in human AGS cells assessed as effect on total protein at 1 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
18. | ALA5216933 | B | Inhibition of STAT1 phosphorylation in human MGC-803 cells assessed as effect on total protein at 1 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
19. | ALA5216934 | B | Inhibition of STAT5 phosphorylation in human AGS cells assessed as effect on total protein at 1 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature | |
20. | ALA5216935 | B | Inhibition of STAT5 phosphorylation in human MGC-803 cells assessed as effect on total protein at 1 to 3 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5214948 | cell-based format | Scientific Literature |