# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5218239 | Binding | Inhibition of N-terminal His-tagged recombinant human PTP1B expressed in Escherichia coli | Homo sapiens | 12 | ALA5215002 | assay format | Scientific Literature | |
2. | ALA5218240 | Binding | Inhibition of recombinant human TCPTP (1 to 314 residues) expressed in baculovirus-insect cells | Homo sapiens | 6 | ALA5215002 | cell-based format | Scientific Literature | |
3. | ALA5218241 | Binding | Selectivity index, ratio of IC50 for inhibition of recombinant human TCPTP (1 to 314 residues) expressed in baculovirus infected insect cells to IC50 for inhibition of N-terminal His-tagged recombinant human PTP1B expressed in Escherichia coli | Homo sapiens | 6 | ALA5215002 | cell-based format | Scientific Literature | |
4. | ALA5218243 | Binding | Mixed type inhibition of N-terminal His-tagged recombinant human PTP1B expressed in Escherichia coli assessed as reduction in Vmax with increase in Km using varying concentrations of pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by Lineweaver-Burk plot analysis | Homo sapiens | 2 | ALA5215002 | assay format | Scientific Literature | |
5. | ALA5218244 | Binding | Mixed type inhibition of N-terminal His-tagged recombinant human PTP1B expressed in Escherichia coli using pNPP as substrate assessed as inhibition constant preincubated for 15 mins followed by substrate addition and measured after 15 mins by Dixon plot analysis | Homo sapiens | 2 | ALA5215002 | assay format | Scientific Literature | |
6. | ALA5218245 | Binding | Potency index, ratio of Sodium orthovanadate IC50 to test compound IC50 for inhibition of N-terminal His-tagged recombinant human PTP1B expressed in Escherichia coli | Homo sapiens | 1 | ALA5215002 | assay format | Scientific Literature |