| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5217493 | F | Antiviral activity against Enterovirus D68 infected in human RD cells assessed as inhibition of viral replication at 2 uM pretreated with virus for 1 hr followed by compound addition for 1 hr by qRT-PCR analysis | enterovirus D68 | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5217494 | F | Antiviral activity against Enterovirus-D68 STL-2014-12 infected in human RD cells assessed as reduction in virus induced cytopathic effect by measuring ATP level incubated for 72 hrs by cell titer-glo luminescent cell viability assay | enterovirus D68 | 54 | organism-based format | Scientific Literature | ||
| 3. | ALA5217495 | F | Cytotoxicity against human RD cells assessed as inhibition of cell viability by measuring ATP level incubated for 72 hrs by cell titer-glo luminescent cell viability assay | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 4. | ALA5217496 | T | Selectivity index, ratio of CC50 for human RD cells to EC50 for Enterovirus-D68 STL-2014-12 infected in human RD cells to | 49 | cell-based format | Scientific Literature | |||
| 5. | ALA5217503 | A | C0 in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA5217504 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA5217505 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA5217506 | A | AUC(0 to t) in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA5217507 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA5217508 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA5217509 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA5217510 | A | Tmax in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA5217511 | A | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA5217512 | A | AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA5217513 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA5217517 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 1 uM incubated upto 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 17. | ALA5217518 | A | Metabolic stability in Beagle dog liver microsomes assessed as intrinsic clearance at 1 uM incubated upto 60 mins in presence of NADPH by LC-MS/MS analysis | Canis lupus familiaris | 1 | microsome format | Scientific Literature | ||
| 18. | ALA5217519 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM incubated upto 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 19. | ALA5217520 | A | Metabolic stability in rat liver microsomes assessed as half life at 1 uM incubated upto 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 20. | ALA5217521 | A | Metabolic stability in Beagle dog liver microsomes assessed as half life at 1 uM incubated upto 60 mins in presence of NADPH by LC-MS/MS analysis | Canis lupus familiaris | 1 | microsome format | Scientific Literature |
The page will load shortly, Thanks for your patience!