# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5217994 | B | Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by substrate addition and measured by RapdiFire-MS/MS analysis | Homo sapiens | 28 | ALA5214994 | single protein format | Scientific Literature | |
2. | ALA5217996 | B | Inhibition of CBP/p300 in human COLO 320HSR cells assessed as reduction of C-myc levels measured after 24 hrs by HTRF assay | Homo sapiens | 27 | ALA5214994 | cell-based format | Scientific Literature | |
3. | ALA5217997 | P | Lipophilicity, log D of the compound at pH 7.4 by chromatographic method | 18 | ALA5214994 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5217998 | A | Stability in male Wistar Han rat plasma assessed as compound remaining at 1 uM measured up to 4 hrs measured by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | cell-free format | Scientific Literature | |
5. | ALA5218011 | A | Cmax in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | organism-based format | Scientific Literature | |
6. | ALA5218012 | A | AUC (0 to infinity) in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | organism-based format | Scientific Literature | |
7. | ALA5218013 | A | Clearance in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | organism-based format | Scientific Literature | |
8. | ALA5218014 | A | Volume of distribution at steady state in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | organism-based format | Scientific Literature | |
9. | ALA5218015 | A | Half-life in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | organism-based format | Scientific Literature | |
10. | ALA5218016 | A | Mean residence time in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5214994 | organism-based format | Scientific Literature | |
11. | ALA5218019 | B | Inhibition of p300 (unknown origin) using Histone H3 substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
12. | ALA5218020 | B | Inhibition of CBP (unknown origin) using Histone H3 substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
13. | ALA5218021 | B | Inhibition of MYST2 (unknown origin) using Histone H3 substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
14. | ALA5218022 | B | Inhibition of GCN5 (unknown origin) using Histone H3 substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
15. | ALA5218023 | B | Inhibition of MYST4/KAT6B (unknown origin) using Histone H3 substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
16. | ALA5218024 | B | Inhibition of KAT5 (unknown origin) using Histone H2A substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
17. | ALA5218025 | B | Inhibition of pCAF (unknown origin) using Histone H3 substrate at 1 uM relative to control | Homo sapiens | 1 | ALA5214994 | single protein format | Scientific Literature | |
18. | ALA5218026 | B | Inhibition of CBP/p300 in human COLO 320HSR cells assessed as decrease in H3K18 acetylation at 0.3 to 1000 nM measured by western blot analysis | Homo sapiens | 1 | ALA5214994 | cell-based format | Scientific Literature | |
19. | ALA5218027 | B | Inhibition of CBP/p300 in human COLO 320HSR cells assessed as decrease in H3K27 acetylation at 0.3 to 1000 nM measured by western blot analysis | Homo sapiens | 1 | ALA5214994 | cell-based format | Scientific Literature | |
20. | ALA5218028 | B | Inhibition of CBP/p300 in human COLO 320HSR cells assessed as decrease in H3K9 acetylation at 0.3 to 1000 nM measured by western blot analysis | Homo sapiens | 1 | ALA5214994 | cell-based format | Scientific Literature |