# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA668409 | B | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | single protein format | Scientific Literature | ||
2. | ALA668410 | B | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | single protein format | Scientific Literature | ||
3. | ALA668411 | B | Inhibition of the wild-type dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | single protein format | Scientific Literature | ||
4. | ALA668418 | B | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | single protein format | Scientific Literature | ||
5. | ALA668423 | B | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | single protein format | Scientific Literature | ||
6. | ALA667612 | B | Inhibition of the wild-type dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | single protein format | Scientific Literature | ||
7. | ALA762995 | F | Antiplasmodial activity IC50 against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S10) | Plasmodium falciparum | 43 | assay format | Scientific Literature | ||
8. | ALA767132 | F | In vitro antiplasmodial activity (IC50) against Plasmodium falciparum wtTM4/8.2 | Plasmodium falciparum | 43 | organism-based format | Scientific Literature | ||
9. | ALA766285 | F | Relative antiplasmodial activity (IC50) compared to Pyr against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S108N) | Plasmodium falciparum | 6 | organism-based format | Scientific Literature | ||
10. | ALA766289 | F | In vitro relative antiplasmodial activity (IC50) compared to Pyr against Plasmodium falciparum TM4/8.2 wild-type | Plasmodium falciparum | 6 | organism-based format | Scientific Literature | ||
11. | ALA849932 | B | Ratio of Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | single protein format | Scientific Literature | ||
12. | ALA848232 | B | Ratio of Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | single protein format | Scientific Literature | ||
13. | ALA849104 | F | IC50 ratio against Plasmodium falciparum K1CB1/TM4 | Plasmodium falciparum | 43 | organism-based format | Scientific Literature | ||
14. | ALA828776 | B | Inhibition constant against Plasmodium falciparum dihydrofolate reductase | Plasmodium falciparum | 52 | single protein format | Scientific Literature | ||
15. | ALA3579956 | B | Inhibition of human placental HexA using pNPGlcNAc substrate | Homo sapiens | 17 | assay format | Scientific Literature | ||
16. | ALA3579957 | B | Chaperoning efficacy at HexA alpha G269S mutant in ATSD patient fibroblasts assessed as maximum increase in enzyme activity using MUGS substrate incubated for 1 to 2 hrs by spectrofluorometry relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
17. | ALA3579962 | B | Chaperoning efficacy at HexA alpha G269S mutant in ATSD patient fibroblasts assessed as drug level causing maximum increase in enzyme activity using MUGS substrate incubated for 1 to 2 hrs by spectrofluorometry relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
18. | ALA3579963 | T | Toxicity against ATSD patient fibroblasts assessed as reduction in beta-galactosidase activity at >400 uM | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
19. | ALA3579964 | T | Toxicity against ATSD patient fibroblasts assessed as reduction in beta-galactosidase activity at | Homo sapiens | 4 | cell-based format | Scientific Literature |