# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5233304 | A | Proteolytic stability assessed as recombinant human NEP-mediated compound degradation by measuring half life incubated for 24 hrs by LC-MS analysis | Homo sapiens | 10 | ALA5233202 | single protein format | Scientific Literature | |
2. | ALA5233306 | A | Stability in human plasma assessed as half life at 1 mM measured for 24 hrs by LC-MS analysis | Homo sapiens | 13 | ALA5233202 | cell-free format | Scientific Literature | |
3. | ALA5233309 | B | Displacement of [125I]-pyr-1-apelin-13 from EGFP tagged rat apelin receptor expressed in CHO cell membrane incubated for 3 hrs by gamma counter analysis | Rattus norvegicus | 13 | ALA5233202 | cell membrane format | Scientific Literature | |
4. | ALA5233310 | B | Activation of recombinant human APJ receptor expressed in rat Chem-5 cells assessed as increase in Ca2+ mobilization by FLIPR Calcium 6-QF fluorescent dye based assay | Homo sapiens | 13 | ALA5233202 | cell-based format | Scientific Literature | |
5. | ALA5233311 | F | Hypotensive effect in anesthetized wild type mouse assessed as change in mean arterial blood pressure at 1.4 uM/Kg, iv administered via right jugular vein measured for 60 mins | Mus musculus | 13 | ALA5233202 | organism-based format | Scientific Literature | |
6. | ALA5233312 | F | Hypotensive effect in anesthetized wild type mouse assessed as total time duration of hypotensive effect at 1.4 uM/Kg, iv administered via right jugular vein measured for 60 mins | Mus musculus | 13 | ALA5233202 | organism-based format | Scientific Literature |