# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5223238 | Functional | Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in African green monkey Vero 76 cells assessed as reduction in virus-induced cytopathic effect measured after 5 days by neutral red dye uptake analysis | Severe acute respiratory syndrome coronavirus 2 | 4 | ALA5223064 | organism-based format | Scientific Literature | |
2. | ALA5225095 | Binding | Inhibition of SARS-CoV-2 BetaCoV/Wuhan/WIV04/2019 Main protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQ/SGFRKME(Edans) as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5223130 | assay format | Scientific Literature | |
3. | ALA5225096 | Functional | Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in African green monkey Vero 76 cells assessed as reduction in virus induced cytopathic effect measured after 5 days by neutral red dye uptake assay | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5223130 | organism-based format | Scientific Literature | |
4. | ALA5225097 | Functional | Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in African green monkey Vero 76 cells assessed as reduction in virus induced cytopathic effect measured after 3 days by secondary viral yield reduction assay | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5223130 | organism-based format | Scientific Literature | |
5. | ALA5229861 | Binding | Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)-K-amide as substrate assessed as substrate cleavage preincubated for 30 mins followed by substrate addition and measured every 30 sec for 60 cycles by FRET based assay | Severe acute respiratory syndrome coronavirus 2 | 10 | ALA5226382 | cell-based format | Scientific Literature | |
6. | ALA5247344 | Binding | Inhibition of SARS CoV-2 Main protease expressed in Escherichia coli BL21(DE3) by FRET analysis | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5244279 | assay format | Scientific Literature | |
7. | ALA5247345 | Functional | Antiviral activity against SARS CoV USA-WA1/2020 infected in African green monkey Vero 76 cells by CPE assay | Severe acute respiratory syndrome-related coronavirus | 2 | ALA5244279 | organism-based format | Scientific Literature | |
8. | ALA5247346 | Toxicity | Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay | Homo sapiens | 2 | ALA5244279 | cell-based format | Scientific Literature | |
9. | ALA5247347 | Toxicity | Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay | Canis lupus familiaris | 2 | ALA5244279 | cell-based format | Scientific Literature | |
10. | ALA5247349 | Toxicity | Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay | Homo sapiens | 2 | ALA5244279 | cell-based format | Scientific Literature | |
11. | ALA5247350 | Toxicity | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay | Chlorocebus sabaeus | 2 | ALA5244279 | cell-based format | Scientific Literature |