# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5261078 | F | Antiproliferative activity against human MIA PaCa-2 cells assessed as cell viability measured after 72 hrs by MTT assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
2. | ALA5261079 | A | Metabolic stability in mouse plasma assessed as parent compound remaining measured after 6 hrs by LC-MS/MS analysis | Mus musculus | 2 | cell-free format | Scientific Literature | ||
3. | ALA5261080 | A | Metabolic stability in human plasma assessed as parent compound remaining measured after 6 hrs by LC-MS/MS analysis | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
4. | ALA5261081 | A | Metabolic stability in human liver microsomes assessed as half life at 1 uM by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
5. | ALA5261082 | A | Metabolic stability in mouse liver microsomes assessed as half life at 1 uM by LC-MS/MS analysis | Mus musculus | 2 | microsome format | Scientific Literature | ||
6. | ALA5261083 | P | Thermodynamic aqueous solubility of the compound at pH 7.4 measured after 48 hrs by UV-spectrometry method | 2 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA5261084 | T | Cytotoxicity against human ARPE-19 cells assessed as cell viability measured after 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA5261085 | F | Induction of autophagy in human ARPE-19 cells assessed as increase in LC3-2 conversion at 10 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA5261086 | F | Induction of autophagy in human ARPE-19 cells assessed as increase in LC3-labeled punctae at 25 uM measured after 4 hrs by immunofluorescence analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA5261090 | F | Induction of autophagy in human ARPE-19 cells assessed as fold increase in LC3 turnover at 25 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA5261091 | F | Induction of autophagy in human ARPE-19 cells assessed as fold increase in LC3 turnover at 10 uM pretreated for 30 mins with cells followed by incubation for 4 hrs under starvation condition in presence of bafilomycin by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA5261092 | F | Reduction in autophagic flux in human ARPE-19 cells at 25 uM incubated for 4 hrs in complete medium in presence of bafilomycin | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA5261093 | B | Inhibition of mTORC1 in human ARPE19 cells at 10 to 50 uM measured after 4 hrs by Western blot analysis related to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA5261094 | B | Inhibition of mTORC1 in human ARPE19 cells measured after 4 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA5261095 | B | Inhibition of mTORC1 in human ARPE19 cells assessed as decrease in P70/total P70 phosphorylation level at 10 uM measured after 4 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA5261096 | F | Induction of autophagy in human ARPE-19 cells assessed as LC3 level at 25 uM measured after 4 hrs under starvation/refeed condition by immunofluorescence analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA5261097 | F | Induction of autophagy in human ARPE-19 cells assessed as LC3 accumulation at 25 to 50 uM measured after 4 hrs under refeed condition by immunofluorescence analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA5261099 | F | Induction of autophagy in human ARPE-19 cells assessed as appearance of LC3 non-uniformed shapes at 25 uM pretreated for 30 mins with cells followed by incubation for 4 hrs under starvation condition by immunofluorescence analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA5261100 | F | Induction of autophagy in human ARPE-19 cells assessed as LC3 enlarged structures at 25 uM pretreated for 30 mins with cells followed by incubation for 4 hrs under starvation condition by immunofluorescence analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA5261101 | F | Induction of autophagy in human ARPE-19 cells assessed as decrease in LC3-2/actin ratio at 10 uM pretreated for 30 mins with cells followed by incubation for 4 hrs under starvation condition by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |