# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5228446 | Functional | Antileishmanial activity against Leishmania mexicana promastigote infected in mouse J774A.1 cells assessed as inhibition of intracellular amastigotes growth measured after 72 hrs by Renilla luciferase assay system | Leishmania mexicana | 34 | ALA5226332 | organism-based format | Scientific Literature | |
2. | ALA5228447 | Toxicity | Cytotoxicity against mouse J774A.1 cells measured after 1 hr in dark by SYBR Green I assay | Mus musculus | 34 | ALA5226332 | cell-based format | Scientific Literature | |
3. | ALA5228448 | Toxicity | Selectivity index, ratio of EC50 for mouse J774A.1 cells to EC50 for Leishmania mexicana promastigote infected in mouse J774A.1 cell | 34 | ALA5226332 | assay format | Scientific Literature | ||
4. | ALA5228454 | ADME | Metabolic stability in mouse liver microsomes assessed as half life measured upto 4 hrs by UPLC-MS analysis | Mus musculus | 18 | ALA5226332 | microsome format | Scientific Literature | |
5. | ALA5228455 | ADME | Metabolic stability in mouse liver microsomes assessed as clearance measured upto 4 hrs by UPLC-MS analysis | Mus musculus | 18 | ALA5226332 | microsome format | Scientific Literature | |
6. | ALA5228456 | ADME | Half life in BALB/c mouse at 10 mg/kg, iv measured after 24 hrs by LC/MS analysis | Mus musculus | 2 | ALA5226332 | organism-based format | Scientific Literature | |
7. | ALA5228457 | ADME | Cmax in BALB/c mouse at 10 mg/kg, iv measured after 24 hrs by LC/MS analysis | Mus musculus | 2 | ALA5226332 | organism-based format | Scientific Literature | |
8. | ALA5228458 | ADME | Tmax in BALB/c mouse at 10 mg/kg, iv measured after 24 hrs by LC/MS analysis | Mus musculus | 2 | ALA5226332 | organism-based format | Scientific Literature | |
9. | ALA5228459 | ADME | AUC in BALB/c mouse at 10 mg/kg, iv measured after 24 hrs by LC/MS analysis | Mus musculus | 2 | ALA5226332 | organism-based format | Scientific Literature | |
10. | ALA5228460 | ADME | Clearance in BALB/c mouse at 10 mg/kg, iv measured after 24 hrs by LC/MS analysis | Mus musculus | 2 | ALA5226332 | organism-based format | Scientific Literature | |
11. | ALA5228461 | ADME | Volume of distribution in BALB/c mouse at 10 mg/kg, iv measured after 24 hrs by LC/MS analysis | Mus musculus | 2 | ALA5226332 | organism-based format | Scientific Literature | |
12. | ALA5228474 | Functional | Antileishmanial activity against Leishmania Mexicana injected in BALB/c mouse foot pad lesion model assessed as inhibition of lesion size progression during drug administration at 10 mg/kg, ip treated for 10 consecutive days | Leishmania mexicana | 1 | ALA5226332 | organism-based format | Scientific Literature |