# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5224086 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 26 | ALA5223091 | cell-based format | Scientific Literature | |
2. | ALA5224087 | B | Inhibition of recombinant GST-tagged human Eg5 assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 3 | ALA5223091 | single protein format | Scientific Literature | |
3. | ALA5224088 | B | Inhibition of recombinant GST-tagged human CENP-E assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 3 | ALA5223091 | single protein format | Scientific Literature | |
4. | ALA5224089 | F | Induction of mitotic arrest in TP53 mutant human MDA-MB-157 cells assessed as multipolar spindle arrays by measuring pericentriolar material incubated for 24 hrs by mitotic index assay | Homo sapiens | 3 | ALA5223091 | cell-based format | Scientific Literature | |
5. | ALA5224090 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Mus musculus | 23 | ALA5223091 | microsome format | Scientific Literature | |
6. | ALA5224091 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Homo sapiens | 23 | ALA5223091 | microsome format | Scientific Literature |