# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5240393 | B | Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assay | Homo sapiens | 33 | ALA5236642 | single protein format | Scientific Literature | |
2. | ALA5240394 | T | Inhibition of B cell proliferation in PBMC (unknown origin) | Not specified | 17 | ALA5236642 | cell-based format | Scientific Literature | |
3. | ALA5240395 | F | Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4 | Not specified | 2 | ALA5236642 | cell-based format | Scientific Literature | |
4. | ALA5240400 | P | Kinetic solubility of compound at pH 6.8 by shake flask method | 2 | ALA5236642 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA5240401 | P | Kinetic solubility of compound at pH 1.5 by shake flask method | 2 | ALA5236642 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA5240402 | B | Selectivity index, ratio of IC50 for inhibition of ITK (unknown origin) to IC50 for inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assay | Homo sapiens | 1 | ALA5236642 | assay format | Scientific Literature | |
7. | ALA5240403 | B | Selectivity index, ratio of IC50 for inhibition of Tec (unknown origin) to IC50 for inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assay | Homo sapiens | 1 | ALA5236642 | assay format | Scientific Literature | |
8. | ALA5240404 | B | Selectivity index, ratio of IC50 for inhibition of TXK (unknown origin) to IC50 for inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assay | Homo sapiens | 1 | ALA5236642 | assay format | Scientific Literature | |
9. | ALA5240405 | B | Selectivity index, ratio of IC50 for inhibition of LCK (unknown origin) to IC50 for inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assay | Homo sapiens | 1 | ALA5236642 | assay format | Scientific Literature | |
10. | ALA5240406 | A | Apparent permeability from apical to basolateral side in human CaCo-2/TC-7 cells | Homo sapiens | 2 | ALA5236642 | cell-based format | Scientific Literature | |
11. | ALA5240407 | A | Efflux ratio of apparent permeability in in human CaCo-2/TC-7 cells | Homo sapiens | 2 | ALA5236642 | cell-based format | Scientific Literature | |
12. | ALA5240408 | A | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
13. | ALA5240409 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
14. | ALA5240410 | A | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
15. | ALA5240411 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
16. | ALA5240412 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
17. | ALA5240413 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 30 mins in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
18. | ALA5240414 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 1 | ALA5236642 | microsome format | Scientific Literature | |
19. | ALA5240415 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature | |
20. | ALA5240416 | A | Time dependent inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate in the presence of NADPH by LC/MS/MS analysis | Homo sapiens | 2 | ALA5236642 | microsome format | Scientific Literature |