| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5227581 | F | Antimycobacterial activity against Mycobacterium bovis BCG ATCC 35734 assessed as inhibition of bacterial growth incubated for 5 days in 7H9 standard media by broth dilution method | Mycobacterium tuberculosis variant bovis | 57 | organism-based format | Scientific Literature | ||
| 2. | ALA5227582 | P | Aqueous solubility of the compound in aqueous buffer at 100 uM incubated for 24 hrs under agitation condition by UV-Vis spectrophotometric analysis | 12 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA5227583 | A | Effective permeability coefficient of the compound at 500 uM incubated for 18 hrs under agitation condition by PAMPA assay | 7 | assay format | Scientific Literature | |||
| 4. | ALA5227584 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as inhibition of bacterial growth incubated for 7 days by broth dilution method | Mycobacterium tuberculosis | 10 | organism-based format | Scientific Literature | ||
| 5. | ALA5227585 | F | Myco-bactericidal activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as inhibition of bacterial colony formation incubated for 7 days by agar plate method | Mycobacterium tuberculosis | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA5227586 | F | Antimycobacterial activity against Mycobacterium bovis BCG ATCC 35734 assessed as inhibition of bacterial growth incubated for 5 days in 7H9 medium with omission of glycerol by broth dilution method | Mycobacterium tuberculosis variant bovis | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA5227587 | F | Antimycobacterial activity against Mycobacterium bovis BCG ATCC 35734 assessed as inhibition of bacterial growth incubated for 5 days in 7H9 medium with addition of 10% FBS by broth dilution method | Mycobacterium tuberculosis variant bovis | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA5227588 | T | Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay | Chlorocebus sabaeus | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA5227589 | T | Selectivity index, ratio of IC50 for cytotoxicity against African green monkey Vero E6 cells to MIC50 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 | 2 | cell-based format | Scientific Literature | |||
| 10. | ALA5227590 | T | Selectivity index, ratio of IC50 for cytotoxicity against African green monkey Vero E6 cells to MIC50 for antimycobacterial activity against Mycobacterium bovis BCG ATCC 35734 | 2 | cell-based format | Scientific Literature | |||
| 11. | ALA5227591 | A | Half life in rat liver microsomes at 200 uM incubated for 5 mins followed by NADPH addition and measured for 45 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 12. | ALA5227592 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-1 harboring mmpL3 T854C/V258A mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 | 3 | assay format | Scientific Literature | |||
| 13. | ALA5227593 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-2 harboring mmpL3 G758A/G253E mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 | 3 | assay format | Scientific Literature | |||
| 14. | ALA5227594 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-3 harboring mmpL3 T2051G/V684G mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 | 3 | assay format | Scientific Literature | |||
| 15. | ALA5227595 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-4 harboring mmpL3 T2051C/V684A mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 | 3 | assay format | Scientific Literature | |||
| 16. | ALA5227596 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv M16-5 harboring mmpL3 G758A/G253E mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 | 3 | assay format | Scientific Literature | |||
| 17. | ALA5227597 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium bovis BCG B16-1 harboring mmpL3 C1932G/F644L mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium bovis BCG ATCC 35734 | 3 | assay format | Scientific Literature | |||
| 18. | ALA5227598 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium bovis BCG B16-2 harboring mmpL3 C1932A/F644L mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium bovis BCG ATCC 35734 | 3 | assay format | Scientific Literature | |||
| 19. | ALA5227599 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv M33-1 harboring mmpL3 G1927A/V643M mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium tuberculosis H37Rv ATCC 27294 | 3 | assay format | Scientific Literature | |||
| 20. | ALA5227600 | F | Ratio of MIC90 for antimycobacterial activity against Mycobacterium bovis BCG B33-1 harboring mmpL3 C1932G/F644L mutant to MIC90 for antimycobacterial activity against wild type Mycobacterium bovis BCG ATCC 35734 | 3 | assay format | Scientific Literature |
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