| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5223630 | B | Binding affinity to human wild-type double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:0.5 by UV melting assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
| 2. | ALA5223631 | B | Binding affinity to human wild-type double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:1 by UV melting assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
| 3. | ALA5223632 | B | Binding affinity to human wild-type double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:4 by UV melting assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
| 4. | ALA5223633 | B | Binding affinity to human mutant double stranded DNA assessed as thermal stability of compound-DNA complex by measuring melting temperature change in at stoichiometry ratio 1:0.5 by UV melting assay | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 5. | ALA5223634 | B | Binding affinity to human mutant double stranded DNA assessed as thermal stability of compound-DNA complex by measuring change in melting temperature at stoichiometry ratio 1:1 by UV melting assay | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 6. | ALA5223635 | B | Binding affinity to human mutant double stranded DNA assessed as thermal stability of compound-DNA complex by measuring melting change in temperature at stoichiometry ratio 1:4 by UV melting assay | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 7. | ALA5223636 | B | Binding affinity to human 5'-biotin-double stranded DNA assessed as association rate constant by surface plasmon resonance | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 8. | ALA5223637 | B | Binding affinity to human 5'-biotin-double stranded DNA assessed as dissociation rate constant by surface plasmon resonance | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 9. | ALA5223638 | B | Binding affinity to human 5'-biotin-double stranded DNA assessed as dissociation equilibrium constant by surface plasmon resonance | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 10. | ALA5223639 | B | Binding affinity to wild-type double stranded DNA (unknown origin) by assessed as decrease in compound-DNA complex at >=8 uM by competitive electrophoretic mobility shift assay | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 11. | ALA5223640 | B | Binding affinity to human single stranded DNA (unknown origin) by electrophoretic mobility shift assay | Not specified | 3 | assay format | Scientific Literature | ||
| 12. | ALA5223642 | B | Binding affinity to DNA STAT3 binding site of PD-L1 promoter region (unknown origin) assessed as disappearance of band of wild-type double stranded DNA-STAT3 protein complex at > 8 uM by competitive electrophoretic mobility shift assay | Not specified | 2 | assay format | Scientific Literature | ||
| 13. | ALA5223644 | B | Binding affinity to 5'-biotin-double stranded DNA (unknown origin) assessed as saturation of the compound-DNA complex at 350 to 500 nM by surface plasmon resonance | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 14. | ALA5223646 | F | Inhibition of PD-L1 mRNA expression in IFNgamma-induced human HCC827 cells measured for 36 hrs by qRT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA5223647 | F | Inhibition of PD-L1 mRNA expression in IFNgamma-induced human MDA-MB-231 cells measured for 36 hrs by qRT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA5223648 | F | Inhibition of PD-L1 protein expression in IFNgamma-induced human HCC827 cells measured for 36 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA5223649 | F | Inhibition of PD-L1 protein expression in IFNgamma-induced human MDA-MB-231 cells measured for 36 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA5223650 | A | Permeability in nucleus of human MDA-MB-231 cells at 2 uM incubated for 32 hrs by Hoechst 33342 dye based confocal laser scanning microscopic assay | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 19. | ALA5223651 | F | Induction of T-cell mediated cell killing in human HCC827 cells co-cultured with PMA-activated Jurkat T cells assessed as IL-2 production at 8 uM by ELISA relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA5223652 | F | Induction of T-cell mediated cell killing in human MDA-MB-231 cells co-cultured with PMA-activated Jurkat T cells assessed as IL-2 production at 8 uM by ELISA relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature |
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