| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5232306 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 2. | ALA5232309 | T | Cytotoxicity against human mesenchymal bone marrow stem cells measured after 48 hrs by MTT assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 3. | ALA5232310 | B | Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader method | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 4. | ALA5232311 | U | Selectivity ratio of IC50 for human mesenchymal bone marrow stem cells to IC50 for MDA-MB-231 cells measured after 48 hrs by MTT assay | Homo sapiens | 38 | assay format | Scientific Literature | ||
| 5. | ALA5232312 | B | Binding affinity to human caspase 3 in human MDA-MB-231 cells at 5 uM measured after 3 hrs by Cellular thermal shift assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA5232313 | B | Binding affinity to human recombinant caspase 3 at 0.3125 to 5 uM measured after 400 secs by Surface plasmon resonance method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 7. | ALA5232314 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells at 200 nM measured after 48 hrs by immunoprecipitation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5232315 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as decrease of phosphorylated AKT expression measured by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5232316 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as decrease of CDK4 expression measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5232317 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of Bax/Bcl2 ratio at 100 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5232318 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of Bax/Bcl2 ratio at 200 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5232319 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of cytochrome C release at 100 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5232320 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of cytochrome C release at 200 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5232321 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 3 release at 100 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5232322 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 3 release at 200 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5232323 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 9 release at 100 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5232324 | B | Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 9 release at 200 nM measured by Western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5232325 | F | Induction of cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells at G0/G1 phase measured after 48 hrs by PI staining based flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5232326 | F | Induction of mitochondrial apoptosis in human MDA-MB-231 cells measured after 48 hrs by Hoechst 33258/ JC1 staining based flow cytometry assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5232327 | F | Antitumour activity against human MDA-MB-231 cells xenografted in nude mouse assessed as inhibition of tumour growth at 10 mg/kg, po measured after 26 days relative to carboplatin | Homo sapiens | 1 | organism-based format | Scientific Literature |
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