| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250900 | B | Agonist activity at human THRalpha transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay | Homo sapiens | 20 | ALA5247640 | cell-based format | Scientific Literature | |
| 2. | ALA5250901 | B | Agonist activity at human THRbeta transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay | Homo sapiens | 20 | ALA5247640 | cell-based format | Scientific Literature | |
| 3. | ALA5250902 | U | Fold of selectivity, ratio of compound EC50/T3 EC50 for THRalpha to ratio of compound EC50/T3 EC50 for THRbeta | 20 | ALA5247640 | assay format | Scientific Literature | ||
| 4. | ALA5250903 | A | Half life in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5247640 | organism-based format | Scientific Literature | |
| 5. | ALA5250904 | A | Tmax in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5247640 | organism-based format | Scientific Literature | |
| 6. | ALA5250905 | A | Cmax in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5247640 | organism-based format | Scientific Literature | |
| 7. | ALA5250906 | A | AUClast in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA5247640 | organism-based format | Scientific Literature | |
| 8. | ALA5250907 | A | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 3 | ALA5247640 | microsome format | Scientific Literature | |
| 9. | ALA5250908 | A | Metabolic stability in rat liver microsomes assessed as half life | Rattus norvegicus | 3 | ALA5247640 | microsome format | Scientific Literature | |
| 10. | ALA5250909 | A | Metabolic stability in mouse liver microsomes assessed as half life | Mus musculus | 3 | ALA5247640 | microsome format | Scientific Literature | |
| 11. | ALA5250912 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 3 | ALA5247640 | microsome format | Scientific Literature | |
| 12. | ALA5250913 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance | Rattus norvegicus | 3 | ALA5247640 | microsome format | Scientific Literature | |
| 13. | ALA5250914 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 3 | ALA5247640 | microsome format | Scientific Literature | |
| 14. | ALA5250924 | T | Toxicity in ICR mouse assessed as decrease in serum total cholesterol level at 30 mg/kg, po administered as single dose measured after 24 hrs by automated biochemical analyzer | Mus musculus | 3 | ALA5247640 | organism-based format | Scientific Literature |
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