| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5259874 | B | Inhibition of PI3Kalpha (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by ATP and substate addition and measured after 1 hr by ADP-glo reagent based assay | Homo sapiens | 48 | single protein format | Scientific Literature | ||
| 2. | ALA5259875 | B | Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by ATP and substate addition and measured after 1 hr by ADP-glo reagent based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 3. | ALA5259876 | B | Inhibition of PI3Kbeta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by ATP and substate addition and measured after 1 hr by ADP-glo reagent based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 4. | ALA5259877 | B | Inhibition of PI3Kgamma (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by ATP and substate addition and measured after 1 hr by ADP-glo reagent based assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 5. | ALA5259878 | F | Antiproliferative activity against human Kasumi 1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5259879 | F | Antiproliferative activity against human T47D cells expressing PIK3CA mutant assessed as cell growth inhibition incubated for 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA5259880 | A | Half life in mouse at 5 mg/kg, po measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA5259881 | A | Half life in mouse at 1 mg/kg, iv measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5259882 | A | Cmax in mouse at 5 mg/kg, po measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA5259883 | A | Cmax in mouse at 1 mg/kg, iv measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA5259884 | A | AUC(0 to t) in mouse at 5 mg/kg, po measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA5259885 | A | AUC(0 to t) in mouse at 1 mg/kg, iv measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA5259886 | A | Volume of distribution in mouse at 5 mg/kg, po measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5259887 | A | Volume of distribution in mouse at 1 mg/kg, iv measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5259888 | A | Clearance in mouse at 5 mg/kg, po measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5259889 | A | Clearance in mouse at 1 mg/kg, iv measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5259890 | A | Oral bioavailability in mouse at 5 mg/kg measured after 24 hrs by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5259891 | B | Inhibition of PI3K/AKT/mTOR signaling pathway in human T47D cells assessed as reduction in Akt phosphorylation at S473 residue preincubated for 1 hr followed by recombinant human insulin-like growth factor 1 stimulation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5259892 | B | Selectivity ratio of IC50 for PI3Kdelta (unknown origin) over IC50 for PI3Kalpha (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA5259893 | B | Selectivity ratio of IC50 for PI3Kbeta (unknown origin) over IC50 for PI3Kalpha (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature |
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