# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5260451 | Binding | Inhibition of GST-tagged human recombinant PDGFR-alpha (550 to 1089 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | assay format | Scientific Literature | |
2. | ALA5260452 | Binding | Inhibition of His-tagged human recombinant FYN expressed in insect cells at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | cell-based format | Scientific Literature | |
3. | ALA5260453 | Binding | Inhibition of His-tagged human recombinant FES expressed in baculovirus expression system at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | assay format | Scientific Literature | |
4. | ALA5260454 | Binding | Inhibition of His-tagged human recombinant FGFR2 (403 to 822 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | assay format | Scientific Literature | |
5. | ALA5260455 | Binding | Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 mins by HTRF assay | Homo sapiens | 15 | ALA5257147 | single protein format | Scientific Literature | |
6. | ALA5260457 | Binding | Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 20 mins by HTRF assay | Homo sapiens | 15 | ALA5257147 | single protein format | Scientific Literature | |
7. | ALA5260458 | Binding | Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 10 mins by HTRF assay | Homo sapiens | 12 | ALA5257147 | single protein format | Scientific Literature | |
8. | ALA5260460 | Functional | Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/C797S mutant assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay | Mus musculus | 15 | ALA5257147 | cell-based format | Scientific Literature | |
9. | ALA5260461 | Functional | Cytotoxicity against human A-431 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay | Homo sapiens | 12 | ALA5257147 | cell-based format | Scientific Literature | |
10. | ALA5260463 | ADME | Intrinsic clearance in mouse liver microsomes at 1 uM in presence of NADP measured per mg protein by LC-MS/MS analysis | Mus musculus | 4 | ALA5257147 | microsome format | Scientific Literature | |
11. | ALA5260468 | Binding | Inhibition of His-tagged human recombinant PDGFR-beta (558 to 1106 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | assay format | Scientific Literature | |
12. | ALA5260469 | Binding | Inhibition of GST-tagged human recombinant TXK (260 to 527 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | assay format | Scientific Literature | |
13. | ALA5260470 | Binding | Inhibition of His-tagged human recombinant VEGFR2 (789 to 1356 residues) expressed in insect cells at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | cell-based format | Scientific Literature | |
14. | ALA5260471 | Binding | Inhibition of GST-tagged human recombinant VEGFR3 (800 to 1297 residues) Q890H/V1128L/H1146R mutant expressed in insect cells at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | cell-based format | Scientific Literature | |
15. | ALA5260472 | Binding | Inhibition of His-tagged human recombinant BTK expressed in insect cells at 200 nM by Z'-lyte assay | Homo sapiens | 1 | ALA5257147 | cell-based format | Scientific Literature | |
16. | ALA5260473 | Binding | Inhibition of EGFR L858R/T790M mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 20 mins by HTRF assay | Homo sapiens | 1 | ALA5257147 | single protein format | Scientific Literature | |
17. | ALA5260474 | Functional | Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay | Mus musculus | 1 | ALA5257147 | cell-based format | Scientific Literature |