# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5240686 | B | Inhibition of electric eel AChE using ATCI and BTCI as substrate preincubated for 5 mins followed by substrate addition and measured after 3 mins by DTNB-reagent based Ellman's method | Electrophorus electricus | 23 | single protein format | Scientific Literature | ||
2. | ALA5240687 | B | Inhibition of equine serum BuChE using ATCI and BTCI as substrate preincubated for 5 mins followed by substrate addition and measured after 3 mins by DTNB-reagent based Ellman's method | Equus caballus | 25 | cell-free format | Scientific Literature | ||
3. | ALA5240690 | B | Selectivity index, ratio of IC50 for inhibition of equine serum BuChE to IC50 for inhibition of electric eel AChE | 23 | assay format | Scientific Literature | |||
4. | ALA5240691 | F | Antioxidant activity assessed as trolox equivalent of ORAC radical scavenging activity by ORAC assay | 25 | assay format | Scientific Literature | |||
5. | ALA5240692 | B | Inhibition of human erythrocyte AChE using ATCI and BTCI as substrate preincubated for 5 mins followed by substrate addition and measured after 3 mins by DTNB-reagent based Ellman's method | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
6. | ALA5240693 | B | Inhibition of human serum BuChE using ATCI and BTCI as substrate preincubated for 5 mins followed by substrate addition and measured after 3 mins by DTNB-reagent based Ellman's method | Homo sapiens | 15 | cell-free format | Scientific Literature | ||
7. | ALA5240695 | B | Selectivity index, ratio of IC50 for inhibition of human erythrocyte AChE to IC50 for inhibition of human serum BuChE | 13 | assay format | Scientific Literature | |||
8. | ALA5240697 | A | Permeability coefficient of the compound across blood brain barrier incubated for 18 hrs by PAMPA assay | 25 | assay format | Scientific Literature | |||
9. | ALA5240699 | B | Mixed type inhibition of human BuChE assessed as inhibition constant using butyrylthiocholine iodide as substrate by lineweaver-burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
10. | ALA5240700 | T | Cytotoxicity against rat PC12 cells assessed as cell viability at 0.625 to 10 uM measured after 24 hrs by CCK-8 assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
11. | ALA5240701 | T | Cytotoxicity against mouse BV-2 cells assessed as cell viability at 10 uM measured after 24 hrs by CCK-8 assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
12. | ALA5240702 | B | Activation of Nrf2-ARE pathway in rat PC-12 cells assessed as increase in Nrf2 expression level incubated for for 4 to 8 hrs by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
13. | ALA5240703 | B | Activation of Nrf2-ARE pathway in rat PC-12 cells assessed as increase in Nrf2 expression level in nucleus at 1 uM by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
14. | ALA5240704 | B | Activation of Nrf2-ARE pathway in rat PC-12 cells assessed as upregulation of GPX4 expression level incubated for 8 hrs by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
15. | ALA5240705 | B | Activation of Nrf2-ARE pathway in rat PC-12 cells assessed as upregulation of NQO1 expression level incubated for 8 hrs by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
16. | ALA5240706 | T | Acute toxicity in Kunming mouse at >= 2500 mg/kg, IG measured for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA5240707 | T | Acute toxicity in Kunming mouse assessed as effect on body weight at 625 to 2500 mg/kg, po measured at 4 to 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA5240708 | T | Acute toxicity in Kunming mouse assessed as abnormalities in lung at 2500 mg/kg, po measured on day 14 by H and E staining based histopathological analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA5240709 | T | Acute toxicity in Kunming mouse assessed as abnormalities in liver at 2500 mg/kg, po measured on day 14 by H and E staining based histopathological analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA5240710 | T | Acute toxicity in Kunming mouse assessed as abnormalities in brain at 2500 mg/kg, po measured on day 14 by H and E staining based histopathological analysis | Mus musculus | 1 | organism-based format | Scientific Literature |