Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene luminescence assay
Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene luminescence assay relative to control
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 mins in presence of NADPH regenerating system by LC-MS/MS analysis
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 12 mins in presence of NADPH regenerating system by LC-MS/MS analysis
Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH regenerating system measured after 30 mins by LC-MS/MS analysis
Pro-cognitive activity in Wistar rat assessed as attenuation of long-term memory deficit by measuring increase in exploration time for novel object at 1 to 10 mg/kg, po by object recognition test