# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5224086 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 26 | ALA5223091 | cell-based format | Scientific Literature | |
2. | ALA5224090 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Mus musculus | 23 | ALA5223091 | microsome format | Scientific Literature | |
3. | ALA5224091 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Homo sapiens | 23 | ALA5223091 | microsome format | Scientific Literature | |
4. | ALA5224092 | F | Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay | Homo sapiens | 22 | ALA5223091 | cell-based format | Scientific Literature | |
5. | ALA5224093 | F | Antiproliferative activity against human OVCAR-3 cells by nuclear count assay | Homo sapiens | 22 | ALA5223091 | cell-based format | Scientific Literature | |
6. | ALA5224096 | A | Clearance in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
7. | ALA5224097 | A | Volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
8. | ALA5224098 | A | Half life in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
9. | ALA5224099 | A | Cmax in CD-1 mouse at 1 mg/kg, iv and 10 mg/kg, po | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
10. | ALA5224100 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg | Mus musculus | 3 | ALA5223091 | organism-based format | Scientific Literature | |
11. | ALA5224101 | A | Unbound fraction in plasma (unknown origin) by ultracentrifugation | Not specified | 3 | ALA5223091 | cell-free format | Scientific Literature |