# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5228966 | Functional | Antiviral activity against Zika virus PRABC59 infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect at 0.1 to 1 mM cells were pretreated with compound for 24 hrs followed by drug removal and subsequent viral infection for 1 hr and later incubated with compound and measured at 4 days post-infection | Zika virus | 1 | ALA5226344 | organism-based format | Scientific Literature | |
2. | ALA5228967 | Functional | Antiviral activity against Zika virus PRABC59 infected in human Huh-7 cells assessed as log reduction in plaque forming units at 0.1 mM cells were pretreated with compound for 24 hrs followed by drug removal and subsequent viral infection for 1 hr and later incubated with compound and measured at 4 days post-infection | Zika virus | 1 | ALA5226344 | organism-based format | Scientific Literature | |
3. | ALA5228968 | Functional | Antiviral activity against Zika virus PRABC59 infected in human Huh7.5 cells assessed as log reduction in plaque forming units at 0.1 mM cells were pretreated with compound for 24 hrs followed by drug removal and subsequent viral infection for 1 hr and later incubated with compound and measured at 4 days post-infection | Zika virus | 1 | ALA5226344 | organism-based format | Scientific Literature | |
4. | ALA5228969 | Functional | Antiviral activity against West Nile virus infected in African green monkey Vero cells assessed as reduction in virus-induced cytopathic effect at 0.1 to 1 mM cells were pretreated with compound for 24 hrs followed by drug removal and subsequent viral infection for 1 hr and later incubated with compound and measured at 3 days post-infection | West Nile virus | 2 | ALA5226344 | organism-based format | Scientific Literature | |
5. | ALA5228971 | Functional | Antiviral activity against West Nile virus infected in human Huh-7 cells assessed as log reduction in plaque forming units at 1 mM cells were pretreated with compound for 24 hrs followed by drug removal and subsequent viral infection for 1 hr and later incubated with compound and measured at 3 days post-infection | West Nile virus | 1 | ALA5226344 | organism-based format | Scientific Literature | |
6. | ALA5228972 | Functional | Antiviral activity against West Nile virus infected in human Huh7.5 cells assessed as log reduction in plaque forming units at 1 mM cells were pretreated with compound for 24 hrs followed by drug removal and subsequent viral infection for 1 hr and later incubated with compound and measured at 3 days post-infection | West Nile virus | 1 | ALA5226344 | organism-based format | Scientific Literature | |
7. | ALA5228973 | Toxicity | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability at 0.1 to 1 mM incubated for 2 days by Alamar Blue assay | Chlorocebus sabaeus | 2 | ALA5226344 | cell-based format | Scientific Literature | |
8. | ALA5228974 | Toxicity | Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability at 0.1 to 1 mM incubated for 2 days by Alamar Blue assay | Homo sapiens | 2 | ALA5226344 | cell-based format | Scientific Literature | |
9. | ALA5228975 | Toxicity | Cytotoxicity against African green monkey Vero cells assessed as cell viability at 1 mM incubated for 5 days by Alamar Blue assay | Chlorocebus sabaeus | 1 | ALA5226344 | cell-based format | Scientific Literature | |
10. | ALA5228976 | Toxicity | Cytotoxicity against human Huh-7 cells assessed as cell viability at 1 mM incubated for 5 days by Alamar Blue assay | Homo sapiens | 1 | ALA5226344 | cell-based format | Scientific Literature | |
11. | ALA5228978 | ADME | Metabolic stability of the compound in human plasma assessed as parent compound remaining at 2 uM measured upto 2 hrs by LC-MS analysis | Homo sapiens | 1 | ALA5226344 | cell-free format | Scientific Literature | |
12. | ALA5228979 | Physicochemical | Stability of the compound in simulated gastric fluid assessed as parent compound remaining at 200 uM measured after 6 hrs by LC-MS/MS analysis | 1 | ALA5226344 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA5228980 | ADME | Apparent permeability across apical to basolateral side in human Caco-2 cells at 2 to 10 uM incubated for 2 hrs by PAMPA assay | Homo sapiens | 1 | ALA5226344 | cell-based format | Scientific Literature | |
14. | ALA5228981 | ADME | Drug metabolism in human Huh-7 cells transfected with HINT1 assessed as ddhCTP level at 100 uM incubated for 24 hrs measured per 5 million cells by mass spectrometry (Rvb <0.01 nmol) | Homo sapiens | 2 | ALA5226344 | cell-based format | Scientific Literature | |
15. | ALA5228982 | ADME | Drug metabolism in human Huh-7 cells transfected with HINT1 assessed as intracellular concentration of ddhCTP at 100 uM incubated for 24 hrs by mass spectrometry | Homo sapiens | 1 | ALA5226344 | cell-based format | Scientific Literature |