# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5256717 | B | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
2. | ALA5256718 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance preincubation with compound followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Rattus norvegicus | 17 | microsome format | Scientific Literature | ||
3. | ALA5256719 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance preincubation with compound followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Homo sapiens | 17 | microsome format | Scientific Literature | ||
4. | ALA5256720 | A | Apparent permeability of compound across apical to basolateral side in dog MDCK-MDR1 cells incubated for 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 17 | cell-based format | Scientific Literature | ||
5. | ALA5256721 | A | Substrate activity at P-gp in dog MDCK-MDR1 cells assessed as efflux ratio incubated for 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 17 | cell-based format | Scientific Literature | ||
6. | ALA5256722 | P | Kinetic solubility of compound at pH 7.4 at 1 to 100 uM incubated for 2 hrs by UV-visible spectroscopy analysis | 17 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA5256723 | P | Octanol-water partition coefficient, log D of the compound by chromatographic method | 17 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA5256725 | A | Clearance in Sprague-Dawley rat plasma at 1 mg/kg,iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
9. | ALA5256726 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg,iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
10. | ALA5256727 | A | Half life in Sprague-Dawley rat at 1 mg/kg,iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
11. | ALA5256728 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg,iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
12. | ALA5256729 | A | Fraction unbound in Sprague-Dawley rat plasma at 1 mg/kg,iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
13. | ALA5256730 | A | Unbound brain-to-plasma concentration ratio in Sprague-Dawley rat plasma at 1 mg/kg,iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
14. | ALA5256731 | A | AUC (0 to infinity) in Sprague-Dawley rat at 3 mg/kg,po by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
15. | ALA5256732 | A | Cmax in Sprague-Dawley rat at 3 mg/kg,po by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
16. | ALA5256733 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
17. | ALA5256734 | A | Oral absorption in Sprague-Dawley rat at 3 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature |