# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5246483 | B | Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotometric analysis | Homo sapiens | 28 | ALA5244263 | single protein format | Scientific Literature | |
2. | ALA5246484 | B | Inhibition of human FXIa using S-2366 as chromogenic substrate preincubated with enzyme for 10 mins followed by substrate addition by spectrophotometric analysis relative to control | Homo sapiens | 27 | ALA5244263 | single protein format | Scientific Literature | |
3. | ALA5246485 | B | Inhibition of human thrombin at 500 uM by chromogenic substrate hydrolysis assay | Homo sapiens | 27 | ALA5244263 | single protein format | Scientific Literature | |
4. | ALA5246486 | B | Inhibition of FVIIa (unknown origin) at 500 uM by chromogenic substrate hydrolysis assay | Homo sapiens | 27 | ALA5244263 | single protein format | Scientific Literature | |
5. | ALA5246487 | B | Inhibition of human FIXa at 500 uM by chromogenic substrate hydrolysis assay | Homo sapiens | 27 | ALA5244263 | single protein format | Scientific Literature | |
6. | ALA5246488 | B | Inhibition of human FXa using methoxycarbonyl-D-cyclohexylglycyl-Gly-Arg-p-nitroanilide as substrate at 500 uM by chromogenic substrate hydrolysis assay | Homo sapiens | 25 | ALA5244263 | single protein format | Scientific Literature | |
7. | ALA5246489 | B | Inhibition of Kallikrein in human plasma at 500 uM by chromogenic substrate hydrolysis assay | Homo sapiens | 27 | ALA5244263 | cell-free format | Scientific Literature | |
8. | ALA5246490 | B | Inhibition of bovine trypsin using S-2222 as chromogenic substrate at 500 uM by chromogenic substrate hydrolysis assay | Bos taurus | 25 | ALA5244263 | assay format | Scientific Literature | |
9. | ALA5246491 | B | Inhibition of bovine alpha-chymotrypsin at 500 uM by chromogenic substrate hydrolysis assay | Bos taurus | 27 | ALA5244263 | single protein format | Scientific Literature | |
10. | ALA5246492 | B | Selectivity for inhibition of human FXIa over human thrombin | Homo sapiens | 27 | ALA5244263 | assay format | Scientific Literature | |
11. | ALA5246493 | B | Selectivity for inhibition of human FXIa over FVIIa (unknown origin) | Homo sapiens | 27 | ALA5244263 | assay format | Scientific Literature | |
12. | ALA5246494 | B | Selectivity for inhibition of human FXIa over human FIXa | Homo sapiens | 27 | ALA5244263 | assay format | Scientific Literature | |
13. | ALA5246495 | B | Selectivity for inhibition of human FXIa over human FXa | Homo sapiens | 27 | ALA5244263 | assay format | Scientific Literature | |
14. | ALA5246496 | B | Selectivity for inhibition of human FXIa over Kallikrein in human plasma | Homo sapiens | 27 | ALA5244263 | cell-free format | Scientific Literature | |
15. | ALA5246497 | B | Selectivity for inhibition of human FXIa over bovine trypsin | 27 | ALA5244263 | assay format | Scientific Literature | ||
16. | ALA5246498 | B | Selectivity for inhibition of human FXIa over bovine alpha-chymotrypsin | 27 | ALA5244263 | assay format | Scientific Literature | ||
17. | ALA5246501 | B | Non-competitive inhibition of human FXIa assessed as decrease in substrate Vmax with constant Km using S-2366 as chromogenic substrate by Michaelis-Menten based kinetics analysis | Homo sapiens | 1 | ALA5244263 | single protein format | Scientific Literature | |
18. | ALA5246503 | B | Allosteric co-operative binding affinity to active site dansylated human DEGR-FXIa assessed as sigmoidal interaction by measuring change in fluorescence intensity by fluorescence based analysis | Homo sapiens | 1 | ALA5244263 | single protein format | Scientific Literature | |
19. | ALA5246504 | B | Binding affinity to active site dansylated human DEGR-FXIa assessed as maximal change in fluorescence intensity by fluorescence based analysis | Homo sapiens | 2 | ALA5244263 | single protein format | Scientific Literature | |
20. | ALA5246505 | B | Binding affinity to active site dansylated human DEGR-FXIa assessed as change in fluorescence intensity by fluorescence based analysis | Homo sapiens | 2 | ALA5244263 | single protein format | Scientific Literature |