# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA668409 | Binding | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | ALA1135602 | single protein format | Scientific Literature | |
2. | ALA668410 | Binding | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | ALA1135602 | single protein format | Scientific Literature | |
3. | ALA668411 | Binding | Inhibition of the wild-type dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | ALA1135602 | single protein format | Scientific Literature | |
4. | ALA668417 | Binding | Inhibition of mutant C59R+S108N dihydrofolate reductase (DHFR) relative to Pyr | Plasmodium falciparum | 13 | ALA1135602 | single protein format | Scientific Literature | |
5. | ALA668422 | Binding | Inhibition of mutant S108N dihydrofolate reductase (DHFR) relative to Pyr | Plasmodium falciparum | 13 | ALA1135602 | single protein format | Scientific Literature | |
6. | ALA667611 | Binding | Inhibition of Plasmodium falciparum wild-type dihydrofolate reductase (DHFR) relative to Pyrimethamine. | Plasmodium falciparum | 21 | ALA1135602 | single protein format | Scientific Literature | |
7. | ALA849932 | Binding | Ratio of Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | ALA1135602 | single protein format | Scientific Literature | |
8. | ALA848232 | Binding | Ratio of Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | ALA1135602 | single protein format | Scientific Literature | |
9. | ALA849104 | Functional | IC50 ratio against Plasmodium falciparum K1CB1/TM4 | Plasmodium falciparum | 43 | ALA1135602 | organism-based format | Scientific Literature | |
10. | ALA828776 | Binding | Inhibition constant against Plasmodium falciparum dihydrofolate reductase | Plasmodium falciparum | 52 | ALA1138679 | single protein format | Scientific Literature | |
11. | ALA905732 | Binding | Inhibition of Mycobacterium tuberculosis DHFR expressed in Saccharomyces cerevisiae TB5 assessed as yeast growth inhibition after 3 days by radial spoke assay | Mycobacterium tuberculosis | 19 | ALA1143059 | assay format | Scientific Literature | |
12. | ALA905733 | Binding | Inhibition of human DHFR expressed in Saccharomyces cerevisiae TB5 assessed as yeast growth inhibition after 3 days by radial spoke assay | Homo sapiens | 19 | ALA1143059 | assay format | Scientific Literature | |
13. | ALA905734 | Binding | Inhibition of yeast DHFR expressed in Saccharomyces cerevisiae TB5 assessed as yeast growth inhibition by after 3 days by radial spoke assay | Saccharomyces cerevisiae | 19 | ALA1143059 | assay format | Scientific Literature | |
14. | ALA767132 | Functional | In vitro antiplasmodial activity (IC50) against Plasmodium falciparum wtTM4/8.2 | Plasmodium falciparum | 43 | ALA1135602 | organism-based format | Scientific Literature | |
15. | ALA762995 | Functional | Antiplasmodial activity IC50 against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S10) | Plasmodium falciparum | 43 | ALA1135602 | assay format | Scientific Literature |
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