| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239207 | B | Inhibition of bacterial VIM-1 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 38 | ALA5236609 | assay format | Scientific Literature | |
| 2. | ALA5239208 | B | Inhibition of bacterial VIM-2 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 29 | ALA5236609 | assay format | Scientific Literature | |
| 3. | ALA5239209 | B | Inhibition of bacterial VIM-4 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 33 | ALA5236609 | assay format | Scientific Literature | |
| 4. | ALA5239210 | B | Inhibition of bacterial NDM-1 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis by UV-visible spectrophotometry | Bacteria | 26 | ALA5236609 | assay format | Scientific Literature | |
| 5. | ALA5239216 | B | Inhibition of bacterial IMP-1 (unknown origin) expressed in Escherichia coli EXPRESS BL21(DE3) assessed as inhibition constant by measuring rate of substrate hydrolysis at 100 uM by UV-visible spectrophotometry relative to control | Bacteria | 38 | ALA5236609 | assay format | Scientific Literature | |
| 6. | ALA5239220 | B | Inhibition of bacterial NDM-1 (unknown origin) assessed as Zn(II) content in protein at 48 uM at 48 uM by overnight equilibrium dialysis | Bacteria | 2 | ALA5236609 | assay format | Scientific Literature | |
| 7. | ALA5239221 | B | Inhibition of bacterial VIM-2 (unknown origin) assessed as decrease in Zn(II) content in protein at 50 uM by native MS analysis | Bacteria | 2 | ALA5236609 | assay format | Scientific Literature | |
| 8. | ALA5239224 | B | Binding affinity to Zn(II) assessed as dissociation constant by isothermal calorimetric assay | Not specified | 2 | ALA5236609 | assay format | Scientific Literature | |
| 9. | ALA5239225 | B | Binding affinity to Zn(II) assessed as change in enthalpy by isothermal calorimetric assay | Not specified | 2 | ALA5236609 | assay format | Scientific Literature | |
| 10. | ALA5239226 | B | Binding affinity to bacterial VIM-2 (unknown origin) assessed as association constant by isothermal calorimetric assay | Bacteria | 1 | ALA5236609 | assay format | Scientific Literature | |
| 11. | ALA5239227 | B | Binding affinity to bacterial VIM-2 (unknown origin) assessed as dissociation constant by isothermal calorimetric assay | Bacteria | 1 | ALA5236609 | assay format | Scientific Literature | |
| 12. | ALA5239228 | B | Binding affinity to bacterial VIM-2 (unknown origin) assessed as Gibbs free energy by isothermal calorimetric assay | Bacteria | 1 | ALA5236609 | assay format | Scientific Literature | |
| 13. | ALA5239229 | B | Binding affinity to bacterial VIM-2 (unknown origin) assessed as change in enthalpy by isothermal calorimetric assay | Bacteria | 1 | ALA5236609 | assay format | Scientific Literature | |
| 14. | ALA5239230 | B | Binding affinity to bacterial VIM-2 (unknown origin) assessed as change in entropy by isothermal calorimetric assay | Bacteria | 1 | ALA5236609 | assay format | Scientific Literature | |
| 15. | ALA5239231 | B | Chelation of Zn(II) in bacterial VIM-2 (unknown origin) by isothermal calorimetric assay | Not specified | 2 | ALA5236609 | assay format | Scientific Literature | |
| 16. | ALA5239232 | B | Chelation of Zn(II) in bacterial NDM-1 (unknown origin) by isothermal calorimetric assay | Not specified | 2 | ALA5236609 | assay format | Scientific Literature | |
| 17. | ALA5239233 | F | Antimicrobial activity against blaVIM-1-producing multidrug-resistant Klebsiella pneumoniae K47-25 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 16 ug/ml) | Klebsiella pneumoniae | 30 | ALA5236609 | organism-based format | Scientific Literature | |
| 18. | ALA5239234 | F | Antimicrobial activity against blaVIM-4-producing multidrug-resistant Klebsiella pneumoniae VA-416/02 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 16 ug/ml) | Klebsiella pneumoniae | 30 | ALA5236609 | organism-based format | Scientific Literature | |
| 19. | ALA5239235 | F | Antimicrobial activity against blaVIM-2-producing multidrug-resistant Pseudomonas aeruginosa VA-182/00 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 128 ug/ml) | Pseudomonas aeruginosa | 30 | ALA5236609 | organism-based format | Scientific Literature | |
| 20. | ALA5239236 | F | Antimicrobial activity against blaNDM-1-producing multidrug-resistant Escherichia coli SI-004 clinical isolate assessed as meropenem MIC at 32 ug/ml by broth microdilution method (Rvb = 64 ug/ml) | Pseudomonas aeruginosa | 30 | ALA5236609 | organism-based format | Scientific Literature |
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