# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5256813 | Binding | Inhibition of human AMCase using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis at 50 uM preincubated with compound for 20 mins and measured immediately after substrate addition by fluorescence based assay relative to control | Homo sapiens | 22 | ALA5252667 | single protein format | Scientific Literature | |
2. | ALA5256814 | Binding | Inhibition of human AMCase using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis by measuring inhibition constant preincubated with compound for 20 mins and measured immediately after substrate addition by fluorescence based assay | Homo sapiens | 23 | ALA5252667 | single protein format | Scientific Literature | |
3. | ALA5256815 | Binding | Inhibition of human CHIT1 using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis at 50 uM preincubated with compound for 20 mins and measured immediately after substrate addition by fluorescence based assay relative to control | Homo sapiens | 22 | ALA5252667 | single protein format | Scientific Literature | |
4. | ALA5256816 | Binding | Inhibition of human CHIT1 using 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotriose as substrate assessed as substrate hydrolysis by measuring inhibition constant preincubated with compound for 20 mins and measured immediately after substrate addition by fluorescence based assay relative to control | Homo sapiens | 23 | ALA5252667 | single protein format | Scientific Literature | |
5. | ALA5256819 | Binding | Selectivity index, ratio of Ki for inhibition of human CHIT1 to Ki for inhibition of human AMcase | Homo sapiens | 19 | ALA5252667 | assay format | Scientific Literature | |
6. | ALA5256820 | Physicochemical | Aqueous solubility of the compound by HPLC-UV/MS analysis | 5 | ALA5252667 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5256821 | ADME | Apparent permeability of compound in phosphate buffer by PAMPA assay | 5 | ALA5252667 | assay format | Scientific Literature | ||
8. | ALA5256822 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining in the presence of NADPH generating system by HPLC-UVMS analysis | Homo sapiens | 5 | ALA5252667 | microsome format | Scientific Literature | |
9. | ALA5256823 | ADME | Drug metabolism in human liver microsomes assessed as hydroxylated metabolite formation by HPLC-UVMS analysis | Homo sapiens | 5 | ALA5252667 | microsome format | Scientific Literature |