# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5225027 | F | Antiproliferative activity against human DMS-114 cells assessed as inhibition of cell growth incubated for 120 hrs by MTT assay | Homo sapiens | 2 | ALA5223126 | cell-based format | Scientific Literature | |
2. | ALA5225028 | F | Antiproliferative activity against human NCI-H1581 cells assessed as inhibition of cell growth incubated for 120 hrs by MTT assay | Homo sapiens | 2 | ALA5223126 | cell-based format | Scientific Literature | |
3. | ALA5225035 | B | PROTAC activity at FGFR1/VHL in human MCF7 cells assessed as FGFR1 degradation at 50 to 100 nM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
4. | ALA5225036 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 0.1 to 10 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
5. | ALA5225038 | B | PROTAC activity at FGFR1/VHL in human NCI-H1581 cells assessed as FGFR1 degradation at 0.1 to 10 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
6. | ALA5225040 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
7. | ALA5225041 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
8. | ALA5225042 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM measured after 30 mins by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
9. | ALA5225043 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM measured after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
10. | ALA5225044 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM preincubated with compound 1198 for 1 hrs followed by compound addition and measured after 5 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
11. | ALA5225045 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM preincubated with AZD4547 for 1 hrs followed by compound addition and measured after 5 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
12. | ALA5225046 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM preincubated with MG132 for 1 hrs followed by compound addition and measured after 5 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
13. | ALA5225047 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation at 100 nM preincubated with MLN4924 for 1 hrs followed by compound addition and measured after 5 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
14. | ALA5225048 | B | PROTAC activity at FGFR1/VHL in human DMS-114 cells assessed as FGFR1 degradation by measuring protein recovery at 100 nM preincubated with compound for 12 hrs followed by compound washout and measured at 24 to 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
15. | ALA5225052 | B | PROTAC activity at FGFR1/VHL in FGF-stimulated human DMS-114 cells assessed as FGFR1 degradation by measuring reduction in ERK1/2 phosphorylation at 10 to 1000 nM preincubated with compound for 4 hrs followed by FGF stimulation for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
16. | ALA5225053 | B | PROTAC activity at FGFR1/VHL in FGF-stimulated human DMS-114 cells assessed as FGFR1 degradation by measuring reduction in FGFR phosphorylation at 10 to 1000 nM preincubated with compound for 4 hrs followed by FGF stimulation for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature | |
17. | ALA5225054 | B | PROTAC activity at FGFR1/VHL in FGF-stimulated human DMS-114 cells assessed as FGFR1 degradation by measuring reduction in FRS2alpha phosphorylation at 10 to 1000 nM preincubated with compound for 4 hrs followed by FGF stimulation for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA5223126 | cell-based format | Scientific Literature |